Akihiro Tojo
Dokkyo Medical University
162 Papers
1.9K Citations
Akihiro Tojo is an academic researcher from Dokkyo Medical University. The author has contributed to research in topics: Kidney & Organic anion transporter 1. The author has an hindex of 44, co-authored 162 publications. Previous affiliations of Akihiro Tojo include University of Tokyo & Kyorin University.
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Papers
Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis
Masataka Sata,Akio Saiura,Atsushi Kunisato,Akihiro Tojo,Seiji Okada,Takeshi Tokuhisa,Hisamaru Hirai,Masatoshi Makuuchi,Yasunobu Hirata,Ryozo Nagai +9 more
TL;DR: It is shown that in models of post-angioplasty restenosis, graft vasculopathy and hyperlipidemia-induced atherosclerosis, bone-marrow cells give rise to most of the SMCs that contribute to arterial remodeling, indicating that somatic stem cells contribute to pathological remodeling of remote organs.
1.1K
Effects of NADPH oxidase inhibitor in diabetic nephropathy
Kensuke Asaba,Akihiro Tojo,Akihiro Tojo,Akihiro Tojo,Maristela L. Onozato,Maristela L. Onozato,Maristela L. Onozato,Atsuo Goto,Atsuo Goto,Atsuo Goto,Mark T. Quinn,Mark T. Quinn,Mark T. Quinn,Toshiro Fujita,Toshiro Fujita,Toshiro Fujita,Christopher S. Wilcox,Christopher S. Wilcox,Christopher S. Wilcox +18 more
TL;DR: Activation of NADPH oxidase with translocation of p47phox to the membrane underlies the oxidative stress and limited NO generation, despite enhanced eNOS expression in a model of diabetic nephropathy.
313
Intrarenal handling of proteins in rats using fractional micropuncture technique
Akihiro Tojo,Hitoshi Endou +1 more
TL;DR: The fractional micropuncture procedure provides direct evidence of protein handling along the nephron without extratubular protein contamination, and glomerular filtrated protein concentrations showed no significant difference among the four fractions.
217
Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney
Akihiro Tojo,William J. Welch,Viviane Bremer,Masumi Kimoto,Kenjiro Kimura,Masao Omata,Tadashi Ogawa,Patrick Vallance,Christopher S. Wilcox +8 more
TL;DR: In this article, the authors compared the immunohistochemical distribution of NOS with NG, NG-dimethylarginine dimethylaminohydrolase (DDAH), which inactivates dimethyl arginines (DMA) and L-NMA by hydrolysis to L-citrulline.
205
Interactions of Human Organic Anion Transporters with Diuretics
Habib Hasannejad,Michio Takeda,Kentarou Taki,Ho Jung Shin,Ellappan Babu,Promsuk Jutabha,Suparat Khamdang,Mahmoud Aleboyeh,Maristela L. Onozato,Akihiro Tojo,Atsushi Enomoto,Naohiko Anzai,Shinichi Narikawa,Xiu-Lin Huang,Toshimitsu Niwa,Hitoshi Endou +15 more
TL;DR: HOAT1 may play an important role in the basolateral uptake of thiazides, and hOAT3 in the uptake of loop diuretics, and it was suggested that bumetanide taken up by hO AT3 and/or hOat1 is excreted into the urine by h OAT4.