Akashi Taguchi
University of Tokyo
19 Papers
3 Citations
Akashi Taguchi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Enhancer & Transcriptional regulation. The author has an hindex of 8, co-authored 15 publications.
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Papers
Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.
Sana Raza-Iqbal,Toshiya Tanaka,Motonobu Anai,Takeshi Inagaki,Yoshihiro Matsumura,Kaori Ikeda,Akashi Taguchi,Frank J. Gonzalez,Juro Sakai,Tatsuhiko Kodama +9 more
TL;DR: K-877 regulates the hepatic gene expression as a SPPARMα and thus may improve dyslipidemia as well as metabolic disorders, such as metabolic syndrome and type 2 diabetes, without untoward side effects.
Chd4 choreographs self-antigen expression for central immune tolerance
Yoshihiko Tomofuji,Hiroyuki Takaba,Hiroshi I. Suzuki,Hiroshi I. Suzuki,Rayene Benlaribi,Cristian David Peña Martinez,Yoshihiro Abe,Yasuyuki Morishita,Tadashi Okamura,Akashi Taguchi,Tatsuhiko Kodama,Hiroshi Takayanagi +11 more
TL;DR: The chromatin remodeler Chd4 works with both Fezf2 and Aire to promote promiscuous tissue-restricted antigen expression in medullary thymic epithelial cells, mediating central tolerance in the thymus.
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Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells
Yoshiki Higashijima,Yoshiki Higashijima,Yusuke Matsui,Teppei Shimamura,Ryo Nakaki,Nao Nagai,Shuichi Tsutsumi,Yohei Abe,Verena M. Link,Verena M. Link,Verena M. Link,Mizuko Osaka,Masayuki Yoshida,Ryo Watanabe,Toshihiro Tanaka,Akashi Taguchi,Mai Miura,Xiaoan Ruan,Guoliang Li,Tsuyoshi Inoue,Masaomi Nangaku,Hiroshi Kimura,Tetsushi Furukawa,Hiroyuki Aburatani,Youichiro Wada,Yijun Ruan,Christopher K. Glass,Yasuharu Kanki +27 more
TL;DR: It is reported that lysine demethylases 7A (KDM7A) and 6A (UTX) play crucial roles in tumor necrosis factor (TNF)‐α signaling in endothelial cells (ECs), where they are regulated by a novel TNF‐α‐responsive microRNA, miR‐3679‐5p.
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Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells.
Mari Katsura,Hiromasa Cyou-Nakamine,Hiromasa Cyou-Nakamine,Hiromasa Cyou-Nakamine,Qin Zen,Yang Zen,Hiroko Nansai,Shota Amagasa,Yasuharu Kanki,Tsuyoshi Inoue,Kiyomi Kaneki,Akashi Taguchi,Mika Kobayashi,Toshiyuki Kaji,Tatsuhiko Kodama,Kiyoshi Miyagawa,Youichiro Wada,Nobuyoshi Akimitsu,Hideko Sone +18 more
TL;DR: In vitro results suggest that 496 mGy radiation affects the development of neuronal progenitor cells while altered gene expression was observed at a radiation dose lower than 100 mGy, which would contribute to the elucidation of the clinical and subclinical phenotypes of impaired neuronal development induced by chronic low-dose radiation.
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Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury
Sho Hasegawa,Tsuyoshi Inoue,Tsuyoshi Inoue,Yasuna Nakamura,Yasuna Nakamura,Daichi Fukaya,Daichi Fukaya,Rie Uni,Chia-Hsien Wu,Chia-Hsien Wu,Rie Fujii,Wachirasek Peerapanyasut,Wachirasek Peerapanyasut,Akashi Taguchi,Takahide Kohro,Shintaro Yamada,Mikako Katagiri,Toshiyuki Ko,Seitaro Nomura,Atsuko Ozeki,Etsuo A. Susaki,Hiroki R. Ueda,Nobuyoshi Akimitsu,Youichiro Wada,Issei Komuro,Masaomi Nangaku,Reiko Inagi +26 more
TL;DR: In this paper, the authors performed RNA sequencing of mouse macrophage cell lines to identify the critical gene that mediates the anti-inflammatory effect of β2-adrenergic receptor (Adrb2) signaling.
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