Akash K. George
University of Louisville
35 Papers
13 Citations
Akash K. George is an academic researcher from University of Louisville. The author has contributed to research in topics: Medicine & Cystathionine beta synthase. The author has an hindex of 12, co-authored 34 publications.
Chat about Author
Papers
Hydrogen sulfide epigenetically mitigates bone loss through OPG/RANKL regulation during hyperhomocysteinemia in mice.
TL;DR: It is demonstrated that diet-induced HHcy, a mouse model of metabolite induced osteoporosis, alters homocysteine metabolism by decreasing plasma levels of H2S, which could be used as a novel therapy for HHcy mediated bone loss.
70
Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke.
Nandan K. Mondal,Jyotirmaya Behera,Kimberly E. Kelly,Akash K. George,Pranav K. Tyagi,Neetu Tyagi +5 more
TL;DR: It is suggested that THC epigenetically ameliorates mitochondrial dysfunction in brain vasculature during Ischemic Stroke and also improves neuro‐motor functions in ischemic mice.
65
Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury.
Avisek Majumder,Mahavir Singh,Jyotirmaya Behera,Nicholas T. Theilen,Akash K. George,Neetu Tyagi,Naira Metreveli,Suresh C. Tyagi +7 more
TL;DR: Evidence is provided that NaHS is beneficial in mitigating HHcy-mediated skeletal injury incited by oxidative/ER stress responses, and functional studies revealed that Na HS administration improved muscle fatigability in CBS+/- mice.
Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling.
Akash K. George,Jyotirmaya Behera,Kimberly E. Kelly,Nandan K. Mondal,Kennedy P. Richardson,Neetu Tyagi +5 more
TL;DR: Exercise restored Hcy and H2S to basal levels while ameliorating AL-induced ER stress, diminishing BBB dysfunction and improving cognitive function via ATF6-Herp-signaling, and showed its protective efficacy against Al-induced neurotoxicity.
A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration.
TL;DR: Patients may benefit from H2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity.
32