The objective of this review article is to explain the factors responsible
 for damaged mitochondria and its association with Alzheimer’s disease.
 Alzheimer’s disease (AD) is fairly produced by dysfunctional mitochondria
 that are alternatively caused by excessive reactive oxygen species and
 mitochondrial dynamic imbalance. In the pathogenesis of AD, there is
 important role of many factors including amyloid-beta peptide (A ),
 tau-proteins, and mutations in presenilin-1. Additionally,
 mitochondrial-targeted antioxidants have also been explained because of their
 significance to mitochondrial alterations in AD. Moreover, alteration in
 mitochondrial dynamics is responsible for the generation of segregated,
 damaged mitochondria that are, later on, destroyed through mitochondrial
 autophagy in AD. Finally, various novel models used for studying Alzheimer’s
 disease, have been discussed.

/pdf/genetic-and-non-genetic-factors-responsible-for-13nnx5gbdz.pdf

Genetic and non-genetic factors responsible for mitochondrial failure and Alzheimer’s disease

Value of Apolipoprotein A I (ApoA-I), α1-antitrypsin (α1-AT), actin α (ACTα), fibronectin (FN), haptoglobin (Hp) on the early diagnosis of coronary heart disease (CHD) with unstable angina (UA) blood stasis syndrome was investigated. Severe screening of 30 every cases of plasma samples with qi deficiency and blood stasis syndrome, phlegm and blood stasis syndrome, by western-blot analysis to detect 5 protein expression levels; Logistic regression analysis to analyze the diagnostic accuracy of plasma proteins combination. Detected five features of protein in the two type of CHD, and ApoA-I expression were declined, lower than the control group of healthy people; four proteins expression were significantly higher. By correlation analysis, ApoA-I is positively correlated with HDL and high negative with MCHC; α1- AT is negatively related to MCH; FN and TT are positively correlated; HP and LDL are positively correlated; ACTα and glucose are positively related. α1-AT, FN, HP, ACTα and healthy people are positively related, except ApoA-I. The diagnostic model composed of five proteins is specific. Combination of the characteristic of this protein group may become a new biomarker in the clinical diagnosis.

/pdf/study-on-the-plasma-protein-joint-diagnostic-value-of-48q1vsnfe7.pdf

Study on the plasma protein joint diagnostic value of coronary heartdisease with unstable angina blood stasis.

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Study on the plasma protein joint diagnostic value of coronary heartdisease with unstable angina blood stasis.