Ajmal Nassar
7 Papers
Ajmal Nassar is an academic researcher. The author has contributed to research in topics: Medicine & microRNA. The author has an hindex of 1, co-authored 3 publications.
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Papers
Astrocytic MicroRNAs and Transcription Factors in Alzheimer’s Disease and Therapeutic Interventions
Ajmal Nassar,Triveni Kodi,Sairaj Satarker,Prasada Chowdari Gurram,Dinesh Upadhya,Fayaz Sm,Jayesh Mudgal,Madhavan Nampoothiri +7 more
TL;DR: A review of the involvement of astrocytic microRNAs that potentially regulate cholesterol metabolism, glutamate uptake, and inflammation in Alzheimer's disease (AD) is presented in this article .
Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic Strategies.
Ajmal Nassar,Sairaj Satarker,Prasada Chowdari Gurram,Dinesh Upadhya,S. M. Fayaz,Madhavan Nampoothiri +5 more
TL;DR: In this article , the role of REST and the influence of various microRNAs in controlling REST function in the progression of Alzheimer's disease (AD), Parkinson disease (PD), and Huntington disease (HD) was studied.
Evaluating the Role of N-Acetyl-L-Tryptophan in the Aβ 1-42-Induced Neuroinflammation and Cognitive Decline in Alzheimer's Disease.
Sairaj Satarker,Prasada Chowdari Gurram,Ajmal Nassar,Suman Manandhar,Rja Vibhavari,Dani Lakshman Yarlagadda,Jayesh Mudgal,Shaila Lewis,Devinder Arora,Madhavan Nampoothiri +9 more
TL;DR: The administration of NAT significantly lowered cognitive decline, neuroinflammatory pathways, and Tau protein and triggered the upregulation of CREB1 signaling, suggesting its neuroprotective role in AD-like conditions.
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Virtual structure-based docking and molecular dynamics of FDA-approved drugs for the identification of potential IKKB inhibitors possessing dopaminergic activity in Alzheimer’s disease
TL;DR: In this article , an in-silico analysis predicted if dopaminergic agonists could have IKKB inhibitory actions, to ameliorate neuroinflammation-associated learning and memory deficits.
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Pharmacological inhibition of RE1 silencing transcription factor disrupts SOX2 expression and neurogenesis in human induced pluripotent stem cells derived neuronal models
Ajmal Nassar,Sumukha Hegde,Divya Chandran,Suryadipali Pahadasingh,Aashika Nayak,Sairaj Satarker,Prasada Chowdari Gurram,Dinesh Upadhya,Madhavan Nampoothiri +8 more