Aime K. Johnson
Auburn University
41 Papers
66 Citations
Aime K. Johnson is an academic researcher from Auburn University. The author has contributed to research in topics: Medicine & Sandhoff disease. The author has an hindex of 13, co-authored 34 publications. Previous affiliations of Aime K. Johnson include University of Kentucky.
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Papers
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
Sourav Roy Choudhury,Zachary Fitzpatrick,Anne F Harris,Stacy Maitland,Jennifer S Ferreira,Yuanfan Zhang,Shan Ma,Rohit Sharma,Heather L. Gray-Edwards,Jacob A. Johnson,Aime K. Johnson,Laura C. Alonso,Claudio Punzo,Kathryn R. Wagner,Casey A. Maguire,Robert M. Kotin,Douglas R. Martin,Miguel Sena-Esteves +17 more
TL;DR: The isolation of a novel CNS tropic AAV capsid, AAV-B1, after a single round of in vivo selection from an AAV Capsid library is reported, which represents an important improvement over AAV9 for CNS gene therapy.
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Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector
Sourav Roy Choudhury,Anne F Harris,Damien J. Cabral,Allison M. Keeler,Ellen Sapp,Jennifer S Ferreira,Heather L. Gray-Edwards,Jacob A. Johnson,Aime K. Johnson,Qin Su,Lorelei Stoica,Marian DiFiglia,Neil Aronin,Douglas R. Martin,Guangping Gao,Miguel Sena-Esteves +15 more
TL;DR: This work investigated the possibility of improving CNS transduction of existing AAV capsids by genetically fusing peptides to the N-terminus of VP2 capsid protein, and found a novel vector AAV-AS, generated by the insertion of a poly-alanine peptide, is capable of extensive gene transfer throughout the CNS after systemic administration in adult mice.
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Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy
Allison M. Bradbury,J. Nicholas Cochran,Victoria J. McCurdy,Aime K. Johnson,Brandon L. Brunson,Heather L. Gray-Edwards,Stanley G. LeRoy,Misako Hwang,Ashley N. Randle,Laura S Jackson,Nancy E. Morrison,Rena C. Baek,Thomas N. Seyfried,Seng H. Cheng,Nancy R. Cox,Henry J. Baker,M. Begoña Cachón-González,Timothy M. Cox,Miguel Sena-Esteves,Douglas R. Martin +19 more
TL;DR: These studies support the therapeutic potential of AAV vectors for SD and underscore the importance of species-specific cDNAs for translational research.
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Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease
Victoria J. McCurdy,Hannah E. Rockwell,Julian R. Arthur,Allison M. Bradbury,Aime K. Johnson,Ashley N. Randle,Brandon L. Brunson,Misako Hwang,Heather L. Gray-Edwards,Nancy E. Morrison,Jacob A. Johnson,Henry J. Baker,Nancy R. Cox,Thomas N. Seyfried,Miguel Sena-Esteves,Douglas R. Martin +15 more
TL;DR: In this article, Adeno-associated virus (AAV) gene therapy achieved global CNS Hex restoration and widespread normalization of storage in the Sandhoff disease (SD) mouse model using a similar treatment approach, and they sought to translate the outcome in mice to the feline SD model as an important step toward human clinical trials.
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AAV-Mediated Gene Delivery in a Feline Model of Sandhoff Disease Corrects Lysosomal Storage in the Central Nervous System
Hannah E. Rockwell,Victoria J. McCurdy,Samuel Eaton,Diane U. Wilson,Aime K. Johnson,Ashley N. Randle,Allison M. Bradbury,Heather L. Gray-Edwards,Henry J. Baker,Judith A. Hudson,Nancy R. Cox,Miguel Sena-Esteves,Thomas N. Seyfried,Douglas R. Martin +13 more
TL;DR: This study demonstrates the therapeutic potential of AAV for feline SD and suggests a similar potential for human SD patients.
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