Ailian Wang
6 Papers
Ailian Wang is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 2 publications.
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Papers
AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity.
Qian Zhang,Shengduo Liu,Chen-Song Zhang,Qirou Wu,Xinyuan Yu,Ruyuan Zhou,Fansen Meng,Ailian Wang,Fei Zhang,Shasha Chen,Xiaojian Wang,Lei Li,Jun Huang,Yaoping Huang,Jian Zou,Jun Qin,Tingbo Liang,Xin-Hua Feng,Sheng-Cai Lin,Pinglong Xu +19 more
TL;DR: In this article , the authors found that viral infection led to a rapid and dramatic decrease in blood glucose levels in rodents, leading to robust AMPK activation, and revealed the molecular mechanism coupling a dual sensing of glucose and nuclei acids, and report its physiological necessity in antiviral defense.
33
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders.
Ailian Wang,Chen Chen,Chen Mei,Shengduo Liu,Cong Xiang,Wen Fang,Fei Zhang,Yifan Xu,Shasha Chen,Qi Zhang,Xueli Bai,Aifu Lin,Dante Neculai,Bing Xia,Cunqi Ye,Jian Zou,Tingbo Liang,Xinhua Feng,Xinran Li,Chengyong Shen,Pinglong Xu +20 more
TL;DR: It is found that various gene abnormalities that cause LSDs, including Hexb, Gla, Npc1, Ctsd and Gba, all shared mutual properties to robustly autoactivate neuron-intrinsic cGAS-STING signalling, driving neuronal death and disease progression.
20
Targeting proteostasis of the HEV replicase to combat infection in preclinical models.
Fei Zhang,Ling-Dong Xu,Qian Zhang,Ailian Wang,Xinyuan Yu,Shengduo Liu,Chu Chen,Shiying Wu,Jian-Wen Jin,Aifu Lin,Dante Neculai,Bin Zhao,Xin-Hua Feng,Tingbo Liang,Pinglong Xu,Yaoping Huang +15 more
TL;DR: In this article , the authors studied a critical pathway for host-HEV interactions and performed a preclinical study of the corresponding antivirals, which target proteostasis of the HEV replicase.
12
Proteasomal processing of the viral replicase ORF1 facilitates HEV-induced liver fibrosis.
Fei Zhang,Shiying Wu,Qirou Wu,Ailian Wang,Shengduo Liu,Qian Zhang,Xinyuan Yu,Bin Wang,Dante Neculai,Bing Xia,Xinhua Feng,Li Shen,Qi Zhang,Tingbo Liang,Yaowei Huang,Pinglong Xu +15 more
TL;DR: This study identifies a proteasome-produced viral protein that potentiates TGF-beta/SMAD signaling, facilitating HEV-induced liver fibrosis and cirrhosis, highlighting complex virus-host interactions and a potential therapeutic target for managing chronic viral diseases.
2
Microglial cGAS-STING signaling underlies glaucoma pathogenesis.
Yutong Liu,Ailian Wang,Chen Chen,Qian Zhang,Qin Shen,Dan Zhang,Xueqi Xiao,Shasha Chen,Lili Lian,Zhenmin Le,Shengduo Liu,Tingbo Liang,Qinxiang Zheng,Pinglong Xu,Jian Zou +14 more