Aileen O’Hearn
United States Department of the Army
5 Papers
Aileen O’Hearn is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Ebola virus & Viral replication. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Aileen O’Hearn include University of Illinois at Chicago.
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Papers
A parallel genome-wide RNAi screening strategy to identify host proteins important for entry of Marburg virus and H5N1 influenza virus
Han Cheng,Katie Koning,Aileen O’Hearn,Minxiu Wang,Emily Rumschlag-Booms,Elizabeth Varhegyi,Lijun Rong +6 more
TL;DR: A genome-wide RNAi screen for identifying the host factors important for Marburg virus and/or avian influenza virus H5N1 as described in this study enables us to identify virus-specific hits with a much lower false positive rate.
Circulating microRNA profiles of Ebola virus infection.
Janice Duy,Jeffrey W. Koehler,Anna N. Honko,Anna N. Honko,Randal J. Schoepp,Nadia Wauquier,Jean-Paul Gonzalez,M. Louise M. Pitt,Eric M. Mucker,Joshua C. Johnson,Joshua C. Johnson,Aileen O’Hearn,James Bangura,Moinya Coomber,Timothy D. Minogue +14 more
TL;DR: EBOV-induced changes in circulating miRNA populations of nonhuman primates (NHPs) and humans are presented and applicability of NHP-derived miRNAs to a human cohort is shown, and with additional research the resulting classifiers could impact the current capability to diagnose presymPTomatic and asymptomatic EBOV infections.
Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry
Aileen O’Hearn,Minxiu Wang,Han Cheng,Calli M. Lear-Rooney,Katie Koning,Emily Rumschlag-Booms,Elizabeth Varhegyi,Gene G. Olinger,Lijun Rong +8 more
TL;DR: It is demonstrated that exostosin 1 (EXT1), which is involved in biosynthesis of heparan sulfate (HS), plays a role in filovirus entry and Expression knockdown of EXT1 by small interfering RNAs (siRNAs) impairs GP-mediated pseudoviral entry and that of infectious EBOV and MARV in tissue cultured cells.
Serosurveillance of viral pathogens circulating in West Africa
Aileen O’Hearn,Matthew A. Voorhees,David P. Fetterer,Nadia Wauquier,Moinya Coomber,James Bangura,Joseph N. Fair,Jean-Paul Gonzalez,Randal J. Schoepp +8 more
TL;DR: A multiplexed MAGPIX® assay to detect IgG antibodies against Lassa, Ebola, Marburg, Rift Valley fever, and Crimean-Congo hemorrhagic fever viruses as well as pan-assays for flaviviruses and alphaviruses is developed and demonstrated the endemic nature of some of these viral pathogens in the region.
Virus-encoded miRNAs in Ebola virus disease
Janice Duy,Anna N. Honko,Louis A. Altamura,Sandra L. Bixler,Suzanne E. Wollen-Roberts,Nadia Wauquier,Aileen O’Hearn,Eric M. Mucker,Joshua C. Johnson,Joshua D. Shamblin,Justine M. Zelko,Miriam Botto,James Bangura,Moinya Coomber,M. Louise M. Pitt,Jean-Paul Gonzalez,Randal J. Schoepp,Arthur J. Goff,Timothy D. Minogue +18 more
TL;DR: Striking similarities in the most abundant miRNAs during infection with different EBOV variants and hosts indicate that these mi RNAs are potential valuable diagnostic markers and key effectors of E BOV pathogenesis.