Aidan Du
9 Papers
Aidan Du is an academic researcher. The author has contributed to research in topics: In silico & RNA splicing. The author has co-authored 3 publications.
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Papers
Tumour-wide RNA splicing aberrations generate actionable public neoantigens.
Darwin Kwok,Nicholas O. Stevers,Inaki Etxeberria,Takahide Nejo,Maggie Colton Cove,Lee H. Chen,Jangham Jung,K. Okada,Senthilnath Lakshmanachetty,M. Gallus,Abhilash Barpanda,Gary Chan,Jerry Liu,Samuel H. Wu,Emilio Ramos,Akane Yamamichi,Payal Watchmaker,Hirokazu Ogino,A. Saijo,Aidan Du,Nadia Grishanina,James Woo,Aaron Diaz,Shawn L. Hervey-Jumper,Susan Marina Chang,Arun P Wiita,Christopher A. Klebanoff,Joseph F Costello,Hideo Okada +28 more
TL;DR: Researchers identify a new class of cancer-specific antigens, "public neoantigens," generated by aberrant RNA splicing in various cancers, which can be targeted by T cells to trigger cancer cell eradication and overcome intratumoural heterogeneity.
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Abstract 3152: Targetable public neoantigens are generated by tumor-wide cancer-specific splicing events in gliomas
Darwin Kwok,Takahide Nejo,Nicholas O. Stevers,Lee Chen,Kaori Okada,Chibo Hong,G Chan,Akane Yamamichi,Aidan Du,Maggie Colton,James Woo,Joseph F. Costello,Hideho Okada +12 more
TL;DR: Kwok et al. as mentioned in this paper developed a comprehensive in silico pipeline for detecting tumor-specific alternative splicing events (neojunctions), and successfully identified tumor-wide, public, alternatively spliced neoantigens (ASNs) that elicited CD8+ T-cell-mediated immune responses.
80 Tumor-specific alternative splicing generates immunogenic spatially-conserved HLA-binding neoantigens detected through integrative transcriptomic and proteomic analyses
Darwin Kwok,Takahide Nejo,Chibo Hong,Aidan Du,Maggie Colton,James Woo,Joseph M. Costello,Hideho Okada +7 more
- 01 Nov 2022
TL;DR: In this paper , the authors investigated alternative-splicing (AS) events within glioma to identify novel MHC-I-presented neoantigens through an integrative transcriptomic and proteomic computational pipeline, complemented by an extensive spatiotemporal analysis of the AS candidates.
Abstract 3907: Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types
Darwin Kwok,Nicholas O. Stevers,Takahide Nejo,Lee H. Chen,Inaki Etxeberria,Jangham Jung,Kaori Okada,Maggie Colton Cove,Senthilnath Lakshmanachetty,Marco Gallus,Abhilash Barpanda,Chibo Hong,Gary Chan,Samuel H. Wu,Emilio Ramos,Akane Yamamichi,J. Liu,Payal Watchmaker,Hirokazu Ogino,Atsuro Saijo,Aidan Du,Nadia Grishanina,James Woo,Aaron A. Diaz,Susan Marina Chang,Joanna J. Phillips,Arun P. Wiita,Christopher A. Klebanoff,Joseph F. Costello,Hideho Okada +29 more
TL;DR: The study identifies novel tumor-specific neoantigens arising from aberrant splicing events and their ability to drive T-cell responses across diverse cancer types.
Abstract 4250: Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens across cancers
Darwin Kwok,Nicholas O. Stevers,Inaki Etxeberria,T. Nejo,Maggie Colton Cove,Lee H. Chen,Jangham Jung,K. Okada,Senthilnath Lakshmanachetty,M. Gallus,Abhilash Barpanda,Chibo Hong,Gary Chan,Jerry Liu,Samuel H. Wu,Emilio Ramos,Akane Yamamichi,Payal Watchmaker,Hirokazu Ogino,A. Saijo,Aidan Du,Nadia R. Grishanina,James Woo,Aaron A. Diaz,Susan Marina Chang,Joanna J Phillips,Arun P Wiita,Christopher A. Klebanoff,Joseph F Costello,H. Okada +29 more