Aïcha Daher
McGill University
25 Papers
93 Citations
Aïcha Daher is an academic researcher from McGill University. The author has contributed to research in topics: RNA & Protein kinase R. The author has an hindex of 13, co-authored 24 publications.
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Papers
TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.
Aïcha Daher,Ghislaine Laraki,Madhurima Singh,Carlos E Melendez-Peña,Sylvie Bannwarth,Antoine H.F.M. Peters,Eliane F. Meurs,Robert E. Braun,Rekha C. Patel,Anne Gatignol +9 more
TL;DR: It is demonstrated that in cells, TRBP controls PACT activation of PKR, an activity that is reversed by stress, demonstrating the relevance of this control in a physiological context.
138
Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions.
Ghislaine Laraki,Guerline Clerzius,Aïcha Daher,Carlos E Melendez-Peña,Sylvanne M Daniels,Anne Gatignol +5 more
TL;DR: It is proposed that the Medipal domain mediates specialized functions through protein-protein interactions and contributes to the RNA interference pathway and to PKR activation.
129
The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.
Guerline Clerzius,Guerline Clerzius,Eileen Shaw,Aïcha Daher,Samantha Burugu,Jean-François Gélinas,Jean-François Gélinas,Thornin Ear,Lucile Sinck,Jean-Pierre Routy,Jean-Pierre Routy,Andrew J. Mouland,Rekha C. Patel,Anne Gatignol +13 more
TL;DR: In contrast to its previously described activity, PACT contributes to PKR dephosphorylation during HIV-1 replication, in addition to its heterodimer formation with TRBP and could be due to its binding to ADAR1.
Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene.
Mariela Duarte,Kenneth Graham,Aïcha Daher,Pier-Luigi Battisti,Sylvie Bannwarth,Emmanuel Ségéral,Kuan-Teh Jeang,Anne Gatignol +7 more
TL;DR: The data indicate that TRBP proteins act at a level prior to Tat function, which could contribute to improved HIV expression in murine models and a differential expression from the cDNAs and post-translational modifications.
35
Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.
Sylvie Bannwarth,Sébastien Lainé,Aïcha Daher,Nathalie Grandvaux,Guerline Clerzius,Andréa C. LeBlanc,John Hiscott,Anne Gatignol +7 more
TL;DR: The studies suggest that the cell specifity of HIV-1 expression and replication may be regulated, in part, through the control of TRBP1 expression.
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