Ahmed Elshazly
24 Papers
3 Citations
Ahmed Elshazly is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
Clinical characteristics and management of hospitalized and ambulatory patients with heart failure–results from ESC heart failure long‐term registry–Egyptian cohort
Mahmoud Hassanein,Magdy Abdelhamid,Bassem Ibrahim,Ahmed Elshazly,Mohamed Wafaie Aboleineen,Hesham Sobhy,Gamela Nasr,Fatma Elmesseiry,Ahmed Abdelmoniem,Medhat Ashmawy,Nabil Farag,Amr A. Youssef,Atef Elbahry,Yahia M. Elrakshy,Mohamed Sobhy,Tarek M. Khairy Abdel Dayem,Hamdy Ebeid,Ashraf Reda,Hesham Boshra,Ayman Saleh,Aldo P. Maggioni +20 more
TL;DR: The clinical characteristics and management of patients hospitalized with acute heart failure and ambulatory patients with chronic heart failure in Egypt are described and compared with heart failure patients from other countries in the European Society of Cardiology‐Heart Failure registry.
An overview of resistance to Human epidermal growth factor receptor 2 (Her2) targeted therapies in breast cancer
Ahmed Elshazly,David Gewirtz +1 more
TL;DR: Some of the recent molecular mechanisms that are involved in the development of resistance to Her2-targeted therapies including the PI3K/Akt/mTOR pathway, IGF-IR, Src, c-MET, the PP2A family, CD36, p27kip1, and miRNAs are discussed.
The Cytoprotective, Cytotoxic and Nonprotective Functional Forms of Autophagy Induced by Microtubule Poisons in Tumor Cells—Implications for Autophagy Modulation as a Therapeutic Strategy
TL;DR: It is speculated as to whether autophagy inhibition could be a practical strategy for improving the response to cancer therapy involving these drugs that have microtubule function as a primary target.
Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective.
TL;DR: In this article , the authors explored the available literature regarding the nature of autophagy induced by these clinically utilized topoisomerase I inhibitors in preclinical tumor models with the goal of determining whether the targeting of autoophagy might have potential as a therapeutic strategy to enhance the antitumor response and/or overcome drug resistance.
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Is Autophagy Inhibition in Combination with Temozolomide a Therapeutically Viable Strategy?
Ahmed Elshazly,David A. Gewirtz +1 more
TL;DR: In this paper , the authors explore the available literature and provide an overview of the evidence for the promotion of protective autophagy in response to temozolomide, highlighting the possibility of targeting auto-ophagy as an adjuvant therapy to potentially increase the effectiveness of the drug and overcome the development of resistance.