Águeda González-Rodríguez
Carlos III Health Institute
90 Papers
301 Citations
Águeda González-Rodríguez is an academic researcher from Carlos III Health Institute. The author has contributed to research in topics: Insulin receptor & Fatty liver. The author has an hindex of 28, co-authored 72 publications. Previous affiliations of Águeda González-Rodríguez include Spanish National Research Council & Complutense University of Madrid.
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Papers
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
Águeda González-Rodríguez,Raúl Mayoral,Noelia Agra,M. P. Valdecantos,Virginia Pardo,María E. Miquilena-Colina,Javier Vargas-Castrillón,O. Lo Iacono,Marco Corazzari,Gian Maria Fimia,Mauro Piacentini,Jordi Muntané,Lisardo Boscá,Carmelo García-Monzón,Paloma Martín-Sanz,Ángela M. Valverde +15 more
TL;DR: The results demonstrated that the autophagic flux is impaired in the liver from both NAFLD patients and murine models ofNAFLD, as well as in lipid-overloaded human hepatocytes, and it could be due to elevated ER stress leading to apoptosis.
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
TL;DR: This review provides succinct insights into the molecular mechanisms responsible for lipotoxicity in NAFLD, including ER and oxidative stress, autophagy, lipoapotosis and inflammation, and highlights the role of CD36/FAT fatty acid translocase inNAFLD pathogenesis.
CHOP is a critical regulator of acetaminophen-induced hepatotoxicity
Dotan Uzi,Liran Barda,Viviana Scaiewicz,Maya Mills,Tobias Mueller,Águeda González-Rodríguez,Ángela M. Valverde,Takao Iwawaki,Yaacov Nahmias,Ramnik J. Xavier,Raymond T. Chung,Boaz Tirosh,Oren Shibolet +12 more
TL;DR: CHOP upregulation during APAP induced liver injury compromises hepatocyte survival in various mechanisms, in part by curtailing the regeneration phase following liver damage, and plays a pro-damage role in response to APAP intoxication.
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SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress
Patricia Rada,Patricia Rada,Virginia Pardo,Virginia Pardo,Maysa A. Mobasher,Maysa A. Mobasher,Maysa A. Mobasher,Irma García-Martínez,Laura Ruiz,Laura Ruiz,Águeda González-Rodríguez,Cristina Sánchez-Ramos,Jordi Muntané,Jordi Muntané,Susana Alemany,Laura P. James,Kenneth J. Simpson,María Monsalve,M. P. Valdecantos,M. P. Valdecantos,Ángela M. Valverde,Ángela M. Valverde +21 more
TL;DR: SIRT1 protein levels are downregulated by IL1β/NFκB signaling in APAP hepatotoxicity, resulting in inflammation and oxidative stress, Thus, maintenance of SIRT1 during APAP overdose by inhibiting NFκB might be clinically relevant.
Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes
Cristina Hernández,Marta García-Ramírez,Lidia Corraliza,Jimena Fernández-Carneado,Josep Farrera-Sinfreu,Berta Ponsati,Águeda González-Rodríguez,Ángela M. Valverde,Rafael Simó +8 more
TL;DR: In this article, topical administration of SST has a potent effect in preventing retinal neurodegeneration induced by diabetes mellitus, and a new preventive pharmacological strategy targeted to early stages of diabetic retinopathy is presented.