Agnieszka Czopik Holt
Yale University
4 Papers
68 Citations
Agnieszka Czopik Holt is an academic researcher from Yale University. The author has contributed to research in topics: Pattern recognition receptor & Innate immune system. The author has an hindex of 4, co-authored 4 publications.
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Papers
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
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Toll-like receptors control activation of adaptive immune responses.
Markus Schnare,Markus Schnare,Gregory M. Barton,Gregory M. Barton,Agnieszka Czopik Holt,Kiyoshi Takeda,Shizuo Akira,Ruslan Medzhitov,Ruslan Medzhitov +8 more
TL;DR: It is shown that MyD88-deficient mice have a profound defect in the activation of antigen-specific T helper type 1 (TH1) but not TH2 immune responses, suggesting that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity.
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Antitumor immunization with a minimal peptide epitope (G9-209-2M) leads to a functionally heterogeneous CTL response.
TL;DR: The results indicated that the CTL response induced by G9-209-2M peptide, a modified epitope of the gp100 melanoma-associated antigen, was highly heterogeneous both in terms of avidity toward the peptide antigen and recognition of tumor cell lines.
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Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88.
TL;DR: It is reported that recognition of CpG DNA requires MyD88, an adaptor protein involved in signal transduction by the Toll-like receptors (TLRs), essential components of innate immune recognition in both Drosophila and mammals.