Agnese A. Pollice
Allegheny General Hospital
23 Papers
276 Citations
Agnese A. Pollice is an academic researcher from Allegheny General Hospital. The author has contributed to research in topics: Cancer & Cytogenetics. The author has an hindex of 13, co-authored 23 publications.
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Papers
Sequential paraformaldehyde and methanol fixation for simultaneous flow cytometric analysis of DNA, cell surface proteins, and intracellular proteins.
Agnese A. Pollice,McCoy Jp,Stanley E. Shackney,Charles A. Smith,Agarwal J,D. R. Burholt,Laura E. Janocko,Francis J. Hornicek,Sarita G. Singh,Robert J. Hartsock +9 more
TL;DR: A cell fixation and permeabilization procedure consisting of sequential paraformaldehyde and methanol was evaluated and found suitable for concomitant flow cytometric quantification of total cellular DNA, immunofluorescence measurements of cell surface proteins, and immunof LU measurements of intracellular proteins.
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Response to trastuzumab, erlotinib, and bevacizumab, alone and in combination, is correlated with the level of human epidermal growth factor receptor-2 expression in human breast cancer cell lines.
David R. Emlet,Kathryn A. Brown,Kociban Dl,Agnese A. Pollice,Charles A. Smith,Ben Brian L Ong,Stanley E. Shackney +6 more
TL;DR: The effects of two and three-drug combinations of trastuzumab, erlotinib, and bevacizumab might offer potential therapeutic advantages in HER2-overexpressing breast cancers, although these effects are of low magnitude, and are likely to be transient.
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Origins and clinical implications of aneuploidy in early bladder cancer.
Stanley E. Shackney,George Berg,Sheryl R. Simon,Jeffrey Cohen,Suresh Amina,William Pommersheim,Robert Yakulis,Scott Wang,Michelle Uhl,Charles A. Smith,Agnese A. Pollice,Robert J. Hartsock +11 more
TL;DR: It is concluded that DNA multiploidy and hypertetraploidy are markers of advanced stages of genetic evolution in human bladder cancer.
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•Journal Article
Correlations Among p53, Her-2/neu, and ras Overexpression and Aneuploidy by Multiparameter Flow Cytometry in Human Breast Cancer: Evidence for a Common Phenotypic Evolutionary Pattern in Infiltrating Ductal Carcinomas
Charles A. Smith,Agnese A. Pollice,Ling-Ping Gu,Kathryn A. Brown,Sarita G. Singh,Laura E. Janocko,Ronald Johnson,Thomas B. Julian,David M. Hyams,Norman Wolmark,Lillian Sweeney,Jan F. Silverman,Stanley E. Shackney +12 more
TL;DR: Whether there are specific sequences of occurrence of these progressive evolutionary changes in human breast cancers by performing correlated cell-by-cell measurements of cell DNA content, p53 protein, Her-2/neu protein, and ras protein by multiparameter flow cytometry is sought.
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Discrepancies between flow cytometric and cytogenetic studies in the detection of aneuploidy in human solid tumors
Stanley E. Shackney,D. R. Burholt,Agnese A. Pollice,Charles A. Smith,Reginald P. Pugh,Robert J. Hartsock +5 more
TL;DR: Overall, 13/20 or 65% of patients with solid tumors in this study had numerical chromosomal abnormalities that were not detected by flow cytometry, and among the tumor cell lines established in culture, the DNA Index was often higher than the cytogenetic index.
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