Ágnes Kasza
University of Szeged
7 Papers
51 Citations
Ágnes Kasza is an academic researcher from University of Szeged. The author has contributed to research in topics: Amyloid beta & Peptide. The author has an hindex of 5, co-authored 6 publications.
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Papers
β-Amyloid pathology in the entorhinal cortex of rats induces memory deficits: Implications for Alzheimer’s disease
Eszter Sipos,Anita Kurunczi,Ágnes Kasza,János Horváth,K. Felszeghy,Serge Laroche,József Toldi,Árpád Párducz,Botond Penke,Zsuzsa Penke,Zsuzsa Penke +10 more
TL;DR: Results show that experimentally-induced amyloid pathology in the entorhinal cortex induces selective cognitive deficits, resembling those observed in early phases of Alzheimer’s disease.
94
Controlled in situ preparation of Aβ(1―42) oligomers from the isopeptide iso-Aβ(1―42) , physicochemical and biological characterization
Zsolt Bozsó,Botond Penke,Botond Penke,Dóra Simon,Ilona Laczkó,Gábor Juhász,Viktor Szegedi,Ágnes Kasza,Katalin Soós,Anasztázia Hetényi,Edit Wéber,Hajnalka Tóháti,Mária Csete,Marta Zarandi,Lívia Fülöp +14 more
TL;DR: It was proven that O-->N acyl migration of the precursor isopeptide results in a water soluble oligomeric mixture of neurotoxic A beta(1-42).
51
Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.
Ágnes Kasza,Ákos Hunya,Zsuzsa Frank,Ferenc Fülöp,Zsolt Török,Gábor Balogh,Miklós Sántha,Árpád Bálind,Sandor Bernath,Katie L.I.M. Blundell,Chrisostomos Prodromou,Ibolya Horváth,Hans-Joachim Zeiler,Philip L. Hooper,László Vígh,Botond Penke +15 more
TL;DR: It is reported that 6 months of LA1011 administration effectively improved the spatial learning and memory functions in wild type mice and eliminated neurodegeneration in double mutant mice, suggesting that the Hsp co-inducer LA 1011 is neuroprotective and therefore is a potential pharmaceutical candidate for the therapy of neurodegenersative diseases, particularly AD.
Patent
SMALL PEPTIDE INHIBITORS OF β-AMYLOID TOXICITY
Lívia Fülöp,Botond Penke,Marta Zarandi,Zsolt Bozsó,Dezso Virok,Tamás Janáky,Yann Verdier,Zsolt László Datki,Viktor Szegedi,Róbert Busa-Fekete,Katalin Soós,Ágnes Kasza,András Kocsor,Ermöke Borbély +13 more
- 08 May 2014
TL;DR: In this paper, an invention aimed at developing treatments of neurodegenerative diseases, particularly Alzheimer's disease (AD), during which accumulation of misfolded and/or aggregated proteins occurs.
2
Motor deficits in homozygous 6 mice as model of Pompe disease
TL;DR: The most effective compound, calcimycin, induced exocytosis through a Ca2+-dependent mechanism, although was unable to release a pool of vesicular glycogen larger than the calcimymycin-induced exocytic pore as discussed by the authors .