Adrian L. Sanborn
Stanford University
24 Papers
964 Citations
Adrian L. Sanborn is an academic researcher from Stanford University. The author has contributed to research in topics: CTCF & Cohesin. The author has an hindex of 13, co-authored 21 publications. Previous affiliations of Adrian L. Sanborn include Baylor College of Medicine & Rice University.
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Papers
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Suhas S.P. Rao,Miriam H. Huntley,Neva C. Durand,Elena K. Stamenova,Ivan D. Bochkov,James T. Robinson,James T. Robinson,Adrian L. Sanborn,Ido Machol,Ido Machol,Arina D. Omer,Arina D. Omer,Eric S. Lander,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden +15 more
TL;DR: In situ Hi-C is used to probe the 3D architecture of genomes, constructing haploid and diploid maps of nine cell types, identifying ∼10,000 loops that frequently link promoters and enhancers, correlate with gene activation, and show conservation across cell types and species.
8.4K
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.
Adrian L. Sanborn,Adrian L. Sanborn,Adrian L. Sanborn,Suhas S.P. Rao,Suhas S.P. Rao,Su Chen Huang,Neva C. Durand,Miriam H. Huntley,Andrew I. Jewett,Ivan D. Bochkov,Dharmaraj Chinnappan,Ashok Cutkosky,Jian Li,Jian Li,Kristopher Geeting,Andreas Gnirke,Alexandre Melnikov,Doug McKenna,Elena K. Stamenova,Elena K. Stamenova,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden,Erez Lieberman Aiden,Erez Lieberman Aiden +24 more
TL;DR: It is shown that it is possible to disrupt, restore, and move loops and domains using targeted mutations as small as a single base pair at CTCF sites, and it is found that the observed contact domains are inconsistent with the equilibrium state for an ordinary condensed polymer.
1.7K
Cohesin Loss Eliminates All Loop Domains
Suhas S.P. Rao,Suhas S.P. Rao,Su Chen Huang,Brian Glenn St Hilaire,Brian Glenn St Hilaire,Jesse M. Engreitz,Elizabeth M. Perez,Kyong-Rim Kieffer-Kwon,Adrian L. Sanborn,Adrian L. Sanborn,Adrian L. Sanborn,Sarah E. Johnstone,Sarah E. Johnstone,Gavin D. Bascom,Ivan D. Bochkov,Xingfan Huang,Xingfan Huang,Muhammad S. Shamim,Muhammad S. Shamim,Jaeweon Shin,Jaeweon Shin,Douglass Turner,Douglass Turner,Ziyi Ye,Ziyi Ye,Arina D. Omer,James T. Robinson,James T. Robinson,James T. Robinson,Tamar Schlick,Tamar Schlick,Tamar Schlick,Bradley E. Bernstein,Bradley E. Bernstein,Rafael Casellas,Eric S. Lander,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden +38 more
TL;DR: In this paper, the effects of degrading cohesin were explored, showing that loop domains can be eliminated and re-formed in under an hour, consistent with a model where loop extrusion is rapid.
1.7K
•Journal Article
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
Adrian L. Sanborn,Suhas S.P. Rao,Su-Chen Huang,Neva C. Durand,Miriam H. Huntley,Andrew I. Jewett,Ivan D. Bochkov,Dharmaraj Chinnappan,Ashok Cutkosky,Jian Li,Kristopher Geeting,Doug McKenna,Elena K. Stamenova,Andreas Gnirke,Alexandre Melnikov,Eric S. Lander,Erez Lieberman Aiden +16 more
TL;DR: In this article, high-resolution spatial proximity maps are consistent with a model in which a complex, including the proteins CCCTC-binding factor (CTCF) and cohesin, mediates the formation of loops by a process of extrusion.
930
Cohesin Loss Eliminates All Loop Domains
Suhas S.P. Rao,Su-Chen Huang,Brian Glenn St Hilaire,Jesse M. Engreitz,Elizabeth M. Perez,Kyong-Rim Kieffer-Kwon,Adrian L. Sanborn,Sarah E. Johnstone,Gavin D. Bascom,Ivan D. Bochkov,Xingfan Huang,Muhammad S. Shamim,Jaeweon Shin,Douglass Turner,Ziyi Ye,Arina D. Omer,James T. Robinson,Tamar Schlick,Bradley E. Bernstein,Rafael Casellas,Erez Lieberman Aiden,Eric S. Lander +21 more
- 01 Oct 2017
TL;DR: All loop domains are eliminated, but neither compartment domains nor histone marks are affected, and many megabase-sized loops recovered in under an hour, consistent with a model where loop extrusion is rapid.
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