Adrian L. Harris
University of Oxford
1115 Papers
15.4K Citations
Adrian L. Harris is an academic researcher from University of Oxford. The author has contributed to research in topics: Angiogenesis & Breast cancer. The author has an hindex of 170, co-authored 1084 publications. Previous affiliations of Adrian L. Harris include Royal College of Surgeons of England & Lawrence Livermore National Laboratory.
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Papers
Phase 1 study of high-dose hydroxyurea in lung cancer.
TL;DR: HU can be given in doses up to 48 g in 48 h 3-weekly with manageable tissue and bone marrow toxicity, and the in vivo blood levels attained are equal to those necessary for effective cell inhibition in an appropriate in vitro model.
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The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.
Claire A. Walsh,Nina Akrap,Elena Garre,Ylva Magnusson,Hannah Harrison,Daniel Andersson,Emma Jonasson,Svanheidur Rafnsdottir,Hani Choudhry,Francesca M. Buffa,Jiannis Ragoussis,Anders Ståhlberg,Anders Ståhlberg,Adrian L. Harris,Göran Landberg +14 more
TL;DR: HMGCS1 is highlighted as a potential gatekeeper for dysregulated mevalonate metabolism important for CSC-features in both luminal and basal breast cancer subtypes and could be a superior novel treatment approach for breast cancer patients via additional CSC blocking functions.
Detection of mammaglobin mRNA in the plasma of breast cancer patients.
Shira Gal,Carrie Fidler,Y.M. Dennis Lo,Kenny Chin,John W. Moore,Adrian L. Harris,James S. Wainscoat +6 more
TL;DR: The aim of this work was to detect cell‐free mammaglobin mRNA in the plasma of breast cancer patients and to investigate whether it can be used as a marker for diagnosis of Breast cancer.
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Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer.
Shahnawaz Rasheed,Adrian L. Harris,Paris P. Tekkis,Helen Turley,Andrew Silver,P J McDonald,Ian C. Talbot,Rob Glynne-Jones,John M. Northover,Thomas Guenther +9 more
TL;DR: MVD was higher in more advanced T- and N-stages and may be used as a determinant of survival in patients with rectal adenocarcinomas, and CA-9 expression was seen more often in earlier Dukes' stages, possibly representing an early tumor hypoxic response.
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Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer.
Alexandra Giatromanolaki,Michael I. Koukourakis,George P. Stathopoulos,Andreas N. Kapsoritakis,Gregorios A. Paspatis,Stylianos Kakolyris,Efthimios Sivridis,Vassilis Georgoulias,Adrian L. Harris,Kevin C. Gatter +9 more
TL;DR: Using the suggested markers more than 80% of locally advanced gastric carcinomas can be grouped in different categories according to their angiogenic profile, which may be useful for phase III trials on novel therapies targeting the major angiogenesis-related features studied here.
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