Adrian L. Harris
University of Oxford
1115 Papers
15.4K Citations
Adrian L. Harris is an academic researcher from University of Oxford. The author has contributed to research in topics: Angiogenesis & Breast cancer. The author has an hindex of 170, co-authored 1084 publications. Previous affiliations of Adrian L. Harris include Royal College of Surgeons of England & Lawrence Livermore National Laboratory.
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Papers
The Role of Copper in Tumour Angiogenesis
TL;DR: A unifying mechanism of action by which copper chelation inhibits endothelial cell proliferation and tumour secretion of angiogenic factors remains to be elucidated, but possible targets include copper-dependent enzymes, chaperones, and transporters.
172
•Journal Article
Inhibition of Colon and Breast Carcinoma Cell Growth by Interleukin-4
TL;DR: IL-4 is a nonautocrine inhibitor of breast carcinoma cell growth and combined treatment with TGF-beta 1 or tamoxifen showed additive inhibition.
Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis.
TL;DR: A comparison of tumour with in vitro hypoxic response profiles and in vivo clustering with seed genes and MicroRNAs and markers of hypoxia and response to treatment are compared.
168
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin.
Alexandra Giatromanolaki,Efthimios Sivridis,Constantinos Kouskoukis,Kevin C. Gatter,Adrian L. Harris,Michael I. Koukourakis +5 more
TL;DR: Overexpression of the transcription factors HIF1α and HIF2α are linked to VEGF expression in nodular malignant melanomas, which are important prognostic factors in these cutaneous tumours.
167
Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer
TL;DR: Understanding the context-specific effects of the Notch pathway will be important for individualized therapies targeting this pathway for both hematologic and solid malignancies.
167