Adrian L. Harris
University of Oxford
1115 Papers
15.4K Citations
Adrian L. Harris is an academic researcher from University of Oxford. The author has contributed to research in topics: Angiogenesis & Breast cancer. The author has an hindex of 170, co-authored 1084 publications. Previous affiliations of Adrian L. Harris include Royal College of Surgeons of England & Lawrence Livermore National Laboratory.
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Papers
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia.
TL;DR: Inhibition of ATF4 represents an attractive stand-alone therapy as well as an opportunity to enhance the efficacy of current chemotherapeutic agents without causing high tissue toxicity to normal tissues.
197
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
TL;DR: It is shown that DNA-damaging modalities used during cancer therapy lead to the release of ssDNA fragments from the cell nucleus into the cytosol, engaging this innate immune response and that the cytoplasmic 3'-5' exonuclease Trex1 is required for their degradation.
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
TL;DR: This review outlines the preclinical and clinical advances in this arena and discusses which cancers may benefit from HIF-targeted therapy.
Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.
TL;DR: A novel HIF-1alpha-independent anoxic mechanism that regulates ATF-4 induction at the protein stability level in tumor cells is demonstrated.
192
miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis
Robert McCormick,C Blick,Jiannis Ragoussis,J Schoedel,David R. Mole,A C Young,Peter Selby,Rosamonde E. Banks,Adrian L. Harris +8 more
TL;DR: It is shown that high miR-210 expression is associated with better clinico-pathological prognostic factors and upregulated microRNA-210 is upregulated in renal cancer compared with normal renal cortex tissue.