Adele M. Musicant
University of North Carolina at Chapel Hill
7 Papers
3 Citations
Adele M. Musicant is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Fusion gene & Autocrine signalling. The author has an hindex of 3, co-authored 7 publications.
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Papers
Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis
Franz X. Schaub,Md. Shamim Reza,Colin A. Flaveny,Weimin Li,Adele M. Musicant,Sany Hoxha,Min Guo,John L. Cleveland,Antonio L. Amelio +8 more
TL;DR: These LumiFluor reporters are inexpensive, robust, noninvasive tools that allow for markedly improved in vivo optical imaging of tumorigenic processes and enables greatly improved spatiotemporal monitoring of very small numbers of tumor cells via in vitro optical imaging.
Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems.
Kshitij Parag-Sharma,Colin P. O'Banion,Erin C. Henry,Adele M. Musicant,John L. Cleveland,David S. Lawrence,Antonio L. Amelio +6 more
TL;DR: A novel BRET-Activated Optogenetics (BEACON) system that employs biologic light to control optogenetic tools and robustly activates a variety of commonly used optogenetics systems in a spatially restricted fashion, and at physiologically relevant time scales, to levels that are achieved by conventional laser/LED light sources.
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Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas.
Kotaro Sato,Kshitij Parag-Sharma,Masahiko Terajima,Adele M. Musicant,Ryan M. Murphy,Matthew R. Ramsey,Hideharu Hibi,Mitsuo Yamauchi,Antonio L. Amelio +8 more
TL;DR: It is found that LH2 overexpression dramatically increases HNSCC cell migratory and invasive abilities in vitro and that LH 2-driven changes in collagen cross-linking robustly induces metastasis in vivo, implicate LH2 as a key regulator of H NSCC tumor invasion and metastasis by modulating collagenCross-link quality and suggest that therapeutic strategies targeting LH2-mediated collagen cross -linking in the TME may be effective in controlling tumor progression and improving disease outcomes.
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CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition.
Adele M. Musicant,Kshitij Parag-Sharma,Weida Gong,Monideepa Sengupta,Arindam Chatterjee,Erin C. Henry,Yi-Hsuan Tsai,Michele C. Hayward,Siddharth Sheth,Renee Betancourt,Trevor Hackman,Ricardo J. Padilla,Joel S. Parker,Jimena Giudice,Colin A. Flaveny,David N. Hayes,Antonio L. Amelio +16 more
TL;DR: In this article, the authors show that the chimeric CRTC1/MAML2 (C1/m2) oncoprotein rewires gene expression programs that promote tumorigenesis.
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Application of bioluminescence resonance energy transfer-based cell tracking approach in bone tissue engineering:
Lufei Wang,Dong Joon Lee,Han Han,Lixing Zhao,Hiroshi Tsukamoto,Yong-Il Kim,Adele M. Musicant,Kshitij Parag-Sharma,Xiangxiang Hu,Henry C. Tseng,Jen-Tsan Chi,Zhengyan Wang,Antonio L. Amelio,Ching-Chang Ko +13 more
TL;DR: Li et al. as discussed by the authors used Bioluminescence resonance energy transfer (BRET) principle to improve BLI cell tracking and generated the brightest bioluminous signal known to date, which enabled more sensitive real-time cell tracking at deep tissue level.
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