Adele Blackler
4 Papers
Adele Blackler is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 4 publications.
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Papers
Quantitative proteomic analysis of HER2 expression in the selection of gastric cancer patients for trastuzumab treatment.
Eunkyung An,C-Y. Ock,Tae Yong Kim,Kiheon Lee,Kiheon Lee,S.-W. Han,S.-W. Han,S-A. Im,S-A. Im,W.L. Liao,Fabiola Cecchi,Adele Blackler,Sheeno Thyparambil,Woo Ho Kim,Jon Burrows,Todd Hembrough,Daniel V.T. Catenacci,D-Y. Oh,D-Y. Oh,Y.-J. Bang,Y.-J. Bang +20 more
TL;DR: Proteomic analysis of HER2 expression demonstrated a quantitative cutoff that improves selection of GC patients for trastuzumab as compared with current diagnostic methods.
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Mass spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: Comparison to IHC and FISH
Daniel V.T. Catenacci,Wei-Li Liao,Lei Zhao,Emma Whitcomb,Les Henderson,Peng Xu,Emily O'Day,Sheeno Thyparambil,Kathleen Bengali,Jamar Uzzell,Marlene Darfler,Fabiola Cecchi,Adele Blackler,David Krisman,Yung-Jue Bang,John Hart,Shu-Yuan Xiao,Sang Mee Lee,Jon Burrows,Todd Hembrough +19 more
TL;DR: Compared to IHC, SRM-MS provided more objective and quantitative Her2 expression with excellent HER2/CEP17 FISH correlation and fewer ‘equivocal’ cases, and demonstrated a refined HER2 expression assay for clinical application.
Therapeutically Induced Changes in HER2, HER3, and EGFR Protein Expression for Treatment Guidance.
Shankar Sellappan,Adele Blackler,Wei-Li Liao,Emily O'Day,Peng Xu,Sheeno Thyparambil,Fabiola Cecchi,Todd Hembrough,Daniel V.T. Catenacci +8 more
TL;DR: By monitoring a single patient through multiple therapies, this report demonstrates how targeted mass spectrometry is an effective, quantitative method that provides real-time analysis of multiple therapeutically associated targeted proteins that can be used to personalize a patient's treatment strategy throughout the course of care.
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Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH
Daniel V.T. Catenacci,Wei-Li Liao,Lei Zhao,Emma Whitcomb,Les Henderson,Emily O'Day,Peng Xu,Sheeno Thyparambil,David Krisman,Kathleen Bengali,Jamar Uzzell,Marlene Darfler,Fabiola Cecchi,Adele Blackler,Yung-Jue Bang,John Hart,Shu-Yuan Xiao,Sang Mee Lee,Jon Burrows,Todd Hembrough +19 more
TL;DR: Compared to IHC, targeted SRM-Her2 proteomics provided more objective and quantitative Her2 expression with excellent HER2/CEP17 FISH correlation and fewer equivocal cases.