Adam Petrone
Broad Institute
6 Papers
16 Citations
Adam Petrone is an academic researcher from Broad Institute. The author has contributed to research in topics: Biology & Ionic liquid. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Adam Petrone include Susquehanna University.
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Papers
Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.
Thomas B. Sundberg,Yanke Liang,Huixian Wu,Hwan Geun Choi,Nam Doo Kim,Taebo Sim,Liv Johannessen,Adam Petrone,Bernard Khor,Daniel B. Graham,Isabel J. Latorre,Andrew J. Phillips,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,José Carlos Rodríguez Pérez,Alykhan F. Shamji,Nathanael S. Gray,Ramnik J. Xavier,Ramnik J. Xavier +19 more
TL;DR: In vivo active doses of YKL-05-099 recapitulate the effects of SIK inhibition on inflammatory cytokine responses, but do not induce metabolic abnormalities observed in Sik2 knockout mice, which support the development of Sik inhibitors for treatment of inflammatory disorders.
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Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease
Elizaveta S. Leshchiner,Elizaveta S. Leshchiner,Jason S. Rush,Michael A. Durney,Zhifang Cao,Zhifang Cao,Vlado Dančík,Benjamin Chittick,Huixian Wu,Adam Petrone,Joshua A. Bittker,Andrew J. Phillips,José Carlos Rodríguez Pérez,Alykhan F. Shamji,Virendar K. Kaushik,Mark J. Daly,Mark J. Daly,Daniel B. Graham,Daniel B. Graham,Stuart L. Schreiber,Stuart L. Schreiber,Ramnik J. Xavier,Ramnik J. Xavier +22 more
TL;DR: The feasibility of using small-molecule inhibitors to recapitulate the antiinflammatory function of CARD9 mutations associated with protection from IBD is demonstrated and biochemical insights into CARD9 variant proteins are used to create a blueprint for IBD therapeutics.
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Tin mediated Barbier type allylation in ionic liquids
TL;DR: The Barbier type allylation of carbonyl compounds is a useful organic transformation as the resultant homoallylic alcohols are important building blocks for many biologically active molecules as mentioned in this paper.
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Tin-Mediated Barbier Type Allylation in Ionic Liquids.
TL;DR: The Barbier type allylation of carbonyl compounds is a useful organic transformation as the resultant homoallylic alcohols are important building blocks for many biologically active molecules as mentioned in this paper.
Abstract 5650: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in CCNE1 amplified cancer cells
Jimmy Fourtounis,John Martino,Rino Stocco,Prasamit S Baruah,Nicole M. Duffy,David Gallo,S. Fournier,Jingjing Li,Li Li,E. G. Aguado,Adam Petrone,Anne Roulston,Yael Mamane,S. Morris,Janek Szychowski,Robert Alexander Papp,M. Zinda,Craig Marshall +17 more
TL;DR: In combination with gemcitabine, RP-6306 demonstrated tumor regression and superior efficacy compared to single agent treatment of either agent alone in multiple CCNE1 amplified models, including HCC1569 and OVCAR3.