Adam J. Black
Pennsylvania State University
7 Papers
Adam J. Black is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Alternative splicing & TNNT3. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Adam J. Black include University of North Carolina at Chapel Hill.
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Papers
More than a messenger: Alternative splicing as a therapeutic target.
TL;DR: A review of recent findings from therapeutic strategies that have used splice switching antisense oligonucleotides and small molecules that bind directly to RNA to correct splicing defects in pathological conditions and an overview of compounds that target kinases and accessory pathways that intersect with the splicing machinery.
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Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.
Weiwei Dai,William P. Miller,Allyson L. Toro,Adam J. Black,Sadie K. Dierschke,Robert P. Feehan,Scot R. Kimball,Michael D. Dennis +7 more
TL;DR: The results support a model wherein Cer‐induced REDD1 expression attenuates TXNIP‐dependent JNK activation and retinal cell death, and both Western diet and C6‐Cer exposure enhanced expression of the stress‐response protein regulated in development and DNA damage response 1 (REDD1).
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Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum.
TL;DR: The data indicate that the leucine or serum-induced suppression of REDD1 expression occurs independent of changes in the rate of degradation of either theREDD1 protein or mRNA.
6
Palmitate- and C6 ceramide-induced Tnnt3 pre-mRNA alternative splicing occurs in a PP2A dependent manner.
TL;DR: The data show that fatty acid saturation level and ceramides are important factors modulating alternative pre-mRNA splicing through activation of PP2A, suggesting that palmitate and ceramide act through PP 2A to modulate Tnnt3 alternative splicing.
RNA processing in skeletal muscle biology and disease.
Emma R Hinkle,Hannah J. Wiedner,Adam J. Black,Jimena Giudice +3 more
- 15 Jan 2019
TL;DR: This review comprehensively summarize recent studies in skeletal muscle that demonstrated the importance of RNA processing, the RNA-binding proteins that are involved, and diseases associated with defects in RNA processing.