Aboul Ella Hassanien

TL;DR: This chapter introduces a secure data processing and transmission schema in WSN and proposes and applies an evaluation criteria for the existing secure clustering algorithms.

Abstract: Abstract Discovering the most effective anti-SARS-CoV-2 drugs is the optimal solution to get back to a normal life without COVID-19. Drug repurposing, also known as drug repositioning, has become one of the most important solutions for developing new COVID-19 drugs. However, this alternative requires long-term laboratory experiments to reach the optimal drug that involves the best combination of drug features to resist the COVID-19 virus. In response to this challenge, the COVID-19 drug repurposing (C19-DR) model based on pigeon-inspired optimizer (PIO) and rough sets theory (RST) is proposed. The proposed model presents a new rough set-based feature selection technique that uses a pigeon-inspired optimizer algorithm to find and validate the optimal reduct of drug features to design an effective COVID-19 drug. Moreover, the proposed model can investigate the efficiency of multiple medications against the COVID-19 virus based on the half-maximal inhibitory concentration (IC50) threshold. The effectiveness of the proposed COVID-19 drug repurposing model has been validated using a laboratory drug dataset consisting of 60 medications. The practical results show that the optimized rough set reduct of {hydrogen bonding acceptor (HBA) and number of chiral centers} is the most significant reduct that can be used to design an effective COVID-19 drug. Moreover, the proposed drug design model could verify the efficiency of a selected dataset of drug models based on evaluating the IC50 metric. The verification results proved the high effectiveness of the proposed model in evaluating the predicted IC50 with an accuracy of 91.4% and MSE of 0.034. These findings might be a promising solution that can assist researchers in developing and repurposing novel medications to treat COVID-19 and its new viral mutants.

Abstract: The main goal of this study is to investigate the relationship between psychosocial variables and diabetic children patients and to obtain a classifier function with which it was possible to classify the patients on the basis of assessed adherence level. The rough set theory is used to identify the most important attributes and to induce decision rules from 302 samples of Kuwaiti diabetic children patients aged 7–13 years old. To increase the efficiency of the classification process, rough sets with Boolean reasoning discretization algorithm is introduced to discretize the data, then the rough set reduction technique is applied to find all reducts of the data which contains the minimal subset of attributes that are associated with a class label for classification. Finally, the rough sets dependency rules are generated directly from all generated reducts. Rough confusion matrix is used to evaluate the performance of the predicted reducts and classes. A comparison between the obtained results using rough sets with decision tree, neural networks, and statistical discriminate analysis classifier algorithms has been made. Rough sets show a higher overall accuracy rates and generate more compact rules.

TL;DR: This study proposes a two-step system using meta-heuristic algorithms (whale, greywolf, flower pollination, and moth flame) for feature selection in breast cancer diagnosis, achieving high accuracy and efficiency in classification tasks.