Abigail Clements
Imperial College London
40 Papers
162 Citations
Abigail Clements is an academic researcher from Imperial College London. The author has contributed to research in topics: Biology & Effector. The author has an hindex of 20, co-authored 35 publications. Previous affiliations of Abigail Clements include McGill University & Monash University, Clayton campus.
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Papers
Infection strategies of enteric pathogenic Escherichia coli
TL;DR: The molecular mechanisms that allow enteric E. coli to colonize and cause disease in the human host are examined and for two of the pathotypes that express a type 3 secretion system (T3SS) the complex interplay between translocated effectors and manipulation of host cell signaling pathways that occurs during infection are discussed.
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MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression
Jonathan J. Wilksch,Ji Yang,Abigail Clements,Jacinta L. Gabbe,Kirsty R. Short,Hanwei Cao,Rosalia Cavaliere,Catherine E. James,Cynthia B. Whitchurch,Mark A. Schembri,Mary L. C. Chuah,Zhao-Xun Liang,Odilia L. C. Wijburg,Adam Jenney,Trevor Lithgow,Richard A. Strugnell +15 more
TL;DR: It is demonstrated for the first time that c-di-GMP can function as an effector to stimulate the activity of a transcriptional activator, and explain how type 3 fimbriae expression is coordinated with other gene expression programs in K. pneumoniae to promote biofilm formation to implanted medical devices.
Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors
Benoit Raymond,Joanna C. Young,Mitchell A. Pallett,Robert G. Endres,Abigail Clements,Gad Frankel +5 more
TL;DR: This review focuses on effectors that subvert signaling pathways that impact on endosomal trafficking, cell survival, and innate immunity, particularly phagocytosis, nuclear factor-κB, and mitogen-activated protein (MAP) kinase pathways and the inflammasome.
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OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo.
Joshua L.C. Wong,Maria Romano,Maria Romano,Louise Kerry,Hok-Sau Kwong,Hok-Sau Kwong,Wen-Wen Low,Stephen J. Brett,Abigail Clements,Konstantinos Beis,Konstantinos Beis,Gad Frankel +11 more
TL;DR: The crystal structure of a clinical ST258 OmpK36 variant is solved, elucidating the mechanism of resistance and consequences on pathogenicity in vivo, and it is suggested that the continuous selective pressure imposed by widespread Carbapenem utilisation in hospital settings drives the expansion of KP expressing Gly-Asp insertion mutants, despite an associated fitness cost.
Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides.
Abigail Clements,Dedreia Tull,Adam Jenney,Jacinta L. Farn,Sang-Hyun Kim,Russell E. Bishop,Joseph B. McPhee,Robert E. W. Hancock,Elizabeth L. Hartland,Elizabeth L. Hartland,Martin J. Pearse,Odilia L. C. Wijburg,David C. Jackson,Malcolm J. McConville,Richard A. Strugnell +14 more
TL;DR: The view that lipopolysaccharide acylation plays a important role in providing Gram-negative bacteria some resistance to structural and innate defenses and especially the antibacterial properties of detergents and cationic defensins is supported.
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