Abhay Dhand
New York Medical College
100 Papers
115 Citations
Abhay Dhand is an academic researcher from New York Medical College. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 36 publications. Previous affiliations of Abhay Dhand include Tufts Medical Center & Westchester Medical Center.
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Papers
Use of Antistaphylococcal β-Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding
Abhay Dhand,Arnold S. Bayer,Arnold S. Bayer,Joe Pogliano,Soo-Jin Yang,Soo-Jin Yang,Michael Bolaris,Victor Nizet,Guiquing Wang,George Sakoulas,George Sakoulas +10 more
TL;DR: In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomecin binding, and decrease in positive surface charge induced by ASBLs against d aptomycin nonsusceptible MRSA.
Antimicrobial Salvage Therapy for Persistent Staphylococcal Bacteremia Using Daptomycin Plus Ceftaroline
George Sakoulas,Pamela A. Moise,Anthony M. Casapao,Poochit Nonejuie,Joshua Olson,Cheryl Y. M. Okumura,Michael J. Rybak,Ravina Kullar,Abhay Dhand,Warren E. Rose,Debra A. Goff,Adam M. Bressler,Yuman Lee,Joe Pogliano,Scott C. Johns,Glenn W. Kaatz,John R. Ebright,Victor Nizet +17 more
TL;DR: Ceftaroline plus daptomycin may be an option to hasten clearance of refractory staphylococcal bacteremia and offers dual benefit via synergy with both d aptomycin and sensitization to innate host defense peptide cathelicidin LL37, which could attenuate virulence of the pathogen.
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Reduced vancomycin susceptibility among clinical Staphylococcus aureus isolates ('the MIC Creep'): implications for therapy.
Abhay Dhand,George Sakoulas +1 more
TL;DR: This review discusses the phenomenon of reduced susceptibility of S. aureus strains to vancomycin, the predictors of infection with such forms of MRSA, and current and future management options.
Nafcillin Enhances Innate Immune-Mediated Killing of Methicillin-Resistant Staphylococcus aureus
George Sakoulas,Cheryl Y. M. Okumura,Cheryl Y. M. Okumura,Wdee Thienphrapa,Joshua Olson,Poochit Nonejuie,Quang Dam,Abhay Dhand,Joe Pogliano,Michael R. Yeaman,Mary E. Hensler,Arnold S. Bayer,Victor Nizet +12 more
TL;DR: In this paper, the effects of nafcillin on host defense peptide (HDP) activity against MRSA were examined in vitro and in vivo, and it was shown that the effect of NAFC on HDP activity was correlated with enhanced killing of S. aureus.
Daptomycin in Combination With Other Antibiotics for the Treatment of Complicated Methicillin-Resistant Staphylococcus aureus Bacteremia
Abhay Dhand,George Sakoulas +1 more
TL;DR: Use of daptomycin in combination with other antibiotics, especially β-lactams, offers a promising treatment option for complicated MRSA bacteremia in which emergence of resistance during treatment may be anticipated.
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