Abdus Samad
11 Papers
Abdus Samad is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 9 publications.
Chat about Author
Papers
Identification of novel inhibitors for SARS-CoV-2 as therapeutic options using machine learning-based virtual screening, molecular docking and MD simulation
Abdus Samad,Amar Ajmal,Arif Mahmood,Beenish Khurshid,Ping Li,Syed Mansoor Jan,Ashfaq Ur Rehman,Pei He,Ashraf N. Abdalla,Muhammad Umair,Junjian Hu,Abdul Wadood +11 more
TL;DR: In this paper , a machine learning-based virtual screening was performed to predict the active phytochemicals against the SARS-CoV-2 3-Chymotrypsin-like protease (3CLPRO), which can be used as a potential drug target.
43
A novel biallelic variant in the Popeye domain‐containing protein 1 (POPDC1) underlies limb girdle muscle dystrophy type 25
Arif Mahmood,Abdus Samad,Abid A. Shah,Abdul Wadood,Afnan Alkathiri,Mohammed Ali Alshehri,Mohammed Zubair Alam,Taimur Hussain,Pei He,Muhammad Umair +9 more
TL;DR: A homozygous missense variant in the POPDC1 gene is identified and functional study of newly identified variant would add key answers to underlying mechanisms of the disease.
11
Structural and dynamics insights into the GBA variants associated with Parkinson's disease.
Arif Mahmood,Abdus Samad,Shazia Bano,Muhammad Umair,Amar Ajmal,Iqra Ilyas,Abid A. Shah,Ping Lei,Junjian Hu +8 more
TL;DR: Sarma et al. as mentioned in this paper used a thorough computational method to pinpoint the structural changes that GBA underwent because of genomic variants and drug binding mechanisms, and found that the PD-linked nsSNP variants of GBA showed structural variation and abnormal dynamics when compared to wild-typ.
6
Clinical and genetic characterization of patients segregating variants in KPTN, MINPP1, NGLY1, AP4B1, and SON underlying neurodevelopmental disorders: Genetic and phenotypic expansion
Asmat Ullah,Abid A. Shah,Majed Alluqmani,Nighat Haider,Hasan Aman,Fatima Al-Fadhli,Ahmad Almatrafi,Alia M. Albalawi,Jai Krihsin,Fati Ullah,Bilal Ali Anjam,Abdullah,Elionora Peña Lozano,Abdus Samad,Wasim Ahmad,Torben Hansen,Kun Xia,Sulman Basit +17 more
TL;DR: The present study expands the phenotypic and genetic spectrum of NDD-associated genes (KPTN, MINPP1, NGLY1, and AP4B1) and determined the deleteriousness of each variant through computational approaches.
6
Comparative binding analysis of WGX50 and Alpha-M with APP family proteins APLP1 and APLP2 using structural-dynamics and free energy calculation approaches.
TL;DR: Wang et al. as mentioned in this paper employed a comparative atomic investigation on Alpha-M and WGX-50 in complex with novel targets, i.e., APLP1 and APLP2, using biophysical and molecular simulation methods.
4