Abdul Raqeeb
University of Calgary
7 Papers
17 Citations
Abdul Raqeeb is an academic researcher from University of Calgary. The author has contributed to research in topics: Extracellular & Receptor. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Abdul Raqeeb include University of Pavia.
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Papers
Purinergic P2Y2 receptors mediate rapid Ca(2+) mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells.
TL;DR: The P2Y2 isoform is identified as the major purinergic receptor in human vascular endothelial cells that mediates the cellular actions of ATP linked to vasorelaxation.
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The Mechanism of Injury-Induced Intracellular Calcium Concentration Oscillations in the Endothelium of Excised Rat Aorta
Roberto Berra-Romani,Abdul Raqeeb,Julián Torres-Jácome,Alejandro Guzman-Silva,Germano Guerra,Franco Tanzi,Francesco Moccia +6 more
TL;DR: These data show for the first time that the coordinated interplay between NCX-mediated Ca2+ entry and InsP3-dependent Ca-dependent release contributes to injury-induced intracellular Ca-induced concentration oscillations.
Ca2+ signaling in injured in situ endothelium of rat aorta.
Roberto Berra-Romani,Roberto Berra-Romani,Abdul Raqeeb,José Everardo Avelino-Cruz,Francesco Moccia,Amanda Oldani,Francisco Speroni,Vanni Taglietti,Franco Tanzi +8 more
TL;DR: It is suggested that endothelium scraping causes a short-lasting stimulation of healthy ECs by extracellular nucleotides released from damaged cells and uncouples the hemichannels of the ECs facing the injury site; these hemich channels do not fully close and allow a long-lasting Ca2+ entry.
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Na+–Ca2+ exchanger contributes to Ca2+extrusion in ATP-stimulated endothelium of intact rat aorta
Roberto Berra-Romani,Abdul Raqeeb,Alejandro Guzman-Silva,Julián Torres-Jácome,Franco Tanzi,Francesco Moccia +5 more
TL;DR: Assessment of the involvement of NCX into the Ca(2+) signals elicited by ATP in intact endothelium of rat aorta shows that, within the same preparation, NCX operates in both modes, depending on the chemical nature of the extracellular stimulus.
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The Duration and Amplitude of the Plateau Phase of ATP- and ADP-Evoked Ca2+ Signals Are Modulated by Ectonucleotidases in in situ Endothelial Cells of Rat Aorta
Roberto Berra-Romani,Chiara Rinaldi,Abdul Raqeeb,Loretta Castelli,Jacopo Magistretti,Vanni Taglietti,Franco Tanzi +6 more
TL;DR: These studies suggest that ATP is able to sustain a prolonged [Ca2+]i increase, unless ectonucleotidase activity reduces the agonist concentration near the EC surface to subthreshold values, quickly cutting the Ca2+ signal.
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