Aaron T. Butt
University of Sheffield
9 Papers
28 Citations
Aaron T. Butt is an academic researcher from University of Sheffield. The author has contributed to research in topics: Burkholderia pseudomallei & Biology. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Aaron T. Butt include University of Exeter.
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Papers
Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species.
Aaron T. Butt,Mark S. Thomas +1 more
TL;DR: The known mechanisms of iron acquisition in pathogenic Burkholderia species are summarized and the evidence for their importance in the context of virulence and the establishment of infection in the host is discussed.
Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.
Muthita Vanaporn,Mitali Sarkar-Tyson,Andrea Kovacs-Simon,Philip M. Ireland,Pornpan Pumirat,Sunee Korbsrisate,Richard W. Titball,Aaron T. Butt +7 more
TL;DR: It is shown that a trehalase deletion mutant (treA) had increased tolerance to thermal stress and produced less biofilm than the wild type B. pseudomallei K96243 strain and that the ΔtreA mutant has reduced ability to survive in macrophages and that it is attenuated in both Galleria mellonella and a mouse infection model.
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Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei.
TL;DR: Type II toxin-antitoxin systems are believed to be widely distributed amongst bacteria although their biological functions are not clear, and eight candidate TA systems in the genome of the human pathogen Burkholderia pseudomallei are identified.
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Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence.
Aaron T. Butt,Nigel Halliday,Paul Williams,Helen S. Atkins,Gregory J. Bancroft,Richard W. Titball +5 more
TL;DR: This study suggests the kynurenine pathway is a critical source of anthranilate and signalling molecules that may regulate B. pseudomallei virulence.
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An efficient system for the generation of marked genetic mutants in members of the genus Burkholderia.
Sravanthi Shastri,Helena L. Spiewak,Aderonke Sofoluwe,Vigdis A. Eidsvaag,Atif H. Asghar,Tyrone Pereira,Edward H. Bull,Aaron T. Butt,Mark S. Thomas +8 more
TL;DR: Improved antibiotic-resistance cassettes that specify resistance to kanamycin, chloramphenicol or trimethoprim effectively in the Burkholderia cepacia complex and related species are described.
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