Aaron Simoni
7 Papers
Aaron Simoni is an academic researcher. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 1, co-authored 2 publications.
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Papers
Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection
Laura Schwartz,Matthew S. Bochter,Aaron Simoni,Kristin Bender,Juan de Dios Ruiz Rosado,Israel Cotzomi-Ortega,Yuriko Itzel Sánchez-Zamora,Brian Becknell,Sarah Linn,Birong Li,Nicholas Santoro,Tad Eichler,John David Spencer +12 more
TL;DR: Ribonuclease 4 and 7 are host defense peptides produced by the kidney and bladder and exhibit bactericidal activity against uropathogenic bacteria and antibiotic-resistant bacteria as discussed by the authors .
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Current and emerging strategies to curb antibiotic-resistant urinary tract infections.
Aaron Simoni,Laura Schwartz,Guillermo Yepes Junquera,Christina B. Ching,John David Spencer +4 more
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Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
Adam J. Rauckhorst,Gabriela Vasquez Martinez,Gabriel Mayoral Andrade,Hsiang Wen,Ji Young Kim,Aaron Simoni,Kranti A. Mapuskar,Prerna Rastogi,Emily J. Steinbach,Michael L. McCormick,Bryan G. Allen,Navjotsingh Pabla,Ashley R. Jackson,Mitchell C. Coleman,Douglas R. Spitz,Eric B. Taylor,Diana Zepeda-Orozco +16 more
TL;DR: In this paper , the authors found that decreased mitochondrial pyruvate uptake is a central adaptive response following acute kidney injury (AKI) and raise the possibility of therapeutically modulating the MPC to attenuate AKI severity.
PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses
Aaron Simoni,Matthew S. Bochter,Sarah Linn-Peirano,Kristin Salamon,Brian Becknell,Hanna Cortado,Ashley R Jackson,Laura Schwartz,John David Spencer +8 more
TL;DR: PTEN modulates bladder urothelial immunity by regulating Akt, NFκB, and FAK signaling, influencing susceptibility to urinary tract infections caused by uropathogenic Escherichia coli, and its deficiency enhances bacterial invasion and inflammation.
Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury.
Adam J. Rauckhorst,Gabriela Vasquez Martinez,Gabriel Mayoral Andrade,Hsiang Wen,Ji Young Kim,Aaron Simoni,Claudia Robles-Planells,Kranti A. Mapuskar,Prerna Rastogi,Emily J. Steinbach,Michael L. McCormick,Bryan G Allen,Navjot S. Pabla,Ashley R. Jackson,Mitchell C. Coleman,D. R. Spitz,Eric B. Taylor,Diana Zepeda-Orozco +17 more
TL;DR: Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect against acute kidney injury, increasing survival and reducing oxidative stress and kidney injury markers in a rhabdomyolysis-induced AKI model.