Aaron Day
Washington University in St. Louis
5 Papers
11 Citations
Aaron Day is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Complement system & Alternative complement pathway. The author has an hindex of 4, co-authored 5 publications.
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Papers
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Lina Ma,Sanjaya Kumar Sahu,Marlene Cano,Vasanthan Kuppuswamy,Jamal Bajwa,Jamal Bajwa,Ja’Nia McPhatter,Ja’Nia McPhatter,Alexander B Pine,Matthew L Meizlish,George Goshua,C. Hong Chang,Hanming Zhang,Christina Price,Parveen Bahel,Henry M. Rinder,Tingting Lei,Aaron Day,Daniel Reynolds,Xiaobo Wu,Rebecca E Schriefer,Adriana M Rauseo,Charles W. Goss,Jane A. O’Halloran,Rachel M. Presti,Alfred H.J. Kim,Andrew E. Gelman,Charles S. Dela Cruz,Alfred Ian Lee,Philip A. Mudd,Hyung J. Chun,John P. Atkinson,Hrishikesh S. Kulkarni +32 more
TL;DR: In this article, the authors investigated complement activation in the plasma from patients with COVID-19 prospectively enrolled at two tertiary care centers: Washington University School of Medicine (n=134) and Yale Medical Center(n=49) and compared their patients to two non-COVID cohorts: (a) patients hospitalized with influenza and (b) patients admitted to the ICU with acute respiratory failure requiring invasive mechanical ventilation (IMV, n=22).
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Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
Lina Ma,Sanjaya Kumar Sahu,Marlene Cano,Vasanthan Kuppuswamy,Jamal Bajwa,Jamal Bajwa,Ja’Nia McPhatter,Ja’Nia McPhatter,Alexander B Pine,Matthew L Meizlish,George Goshua,C-Hong Chang,Hanming Zhang,Christina Price,Parveen Bahel,Henry M. Rinder,Tingting Lei,Aaron Day,Daniel Reynolds,Xiaobo Wu,Rebecca E Schriefer,Adriana M Rauseo,Charles W. Goss,Jane A. O’Halloran,Rachel M. Presti,Alfred H.J. Kim,Andrew E. Gelman,Charles S. Dela Cruz,Alfred Ian Lee,Phillip Mudd,Hyung J. Chun,John P. Atkinson,Hrishikesh S. Kulkarni +32 more
TL;DR: Increased complement activation in COVID-19 compared to influenza and non-COVID respiratory failure is reported, and alternative pathway activation is demonstrated as a key marker of multiorgan failure and death.
Comprehensive Immunologic Evaluation of Bronchoalveolar Lavage Samples from Human Patients with Moderate and Severe Seasonal Influenza and Severe COVID-19.
Daniel Reynolds,Cristina Vazquez Guillamet,Aaron Day,Nicholas Borcherding,Rodrigo Vazquez Guillamet,José Alberto Choreño-Parra,Stacey L. House,Jane A. O’Halloran,Joaquín Zúñiga,Ali H. Ellebedy,Derek E. Byers,Philip A. Mudd +11 more
TL;DR: In this paper, the authors used quantitative multiparameter flow cytometry and multiplex cytokine assays to evaluate matched blood and bronchoalveolar lavage (BAL) samples from control human subjects, subjects with symptomatic seasonal influenza who did not have respiratory failure, and subjects with severe seasonal influenza or SARS-CoV-2 infection with respiratory failure.
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SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell Response.
Jackson S. Turner,Aaron Day,Wafaa B. Alsoussi,Zhuoming Liu,Jane A. O’Halloran,Rachel M. Presti,Bruce K. Patterson,Sean P. J. Whelan,Ali H. Ellebedy,Philip A. Mudd +9 more
TL;DR: In this paper, the authors performed comprehensive immunologic evaluation of one individual with prolonged shedding and showed that detectable viral RNA shedding in the upper airway can occur more than 3 months following SARS-CoV2 infection in some individuals with COVID-19 and suggest that impaired CD8+ T cells may play a role in prolonged viral shedding.
Impaired Cellular Immune Responses During the First Week of Severe Acute Influenza Infection.
Jackson S. Turner,Tingting Lei,Aaron J. Schmitz,Aaron Day,José Alberto Choreño-Parra,Luis Jiménez-Alvarez,Alfredo Cruz-Lagunas,Stacey L. House,Joaquín Zúñiga,Ali H. Ellebedy,Philip A. Mudd +10 more
TL;DR: Antigen-specific CD8+ T cells respond early during acute influenza infection at magnitudes that are lower than responses seen in uninfected individuals.