Aaron A Berlin
AstraZeneca
7 Papers
1 Citations
Aaron A Berlin is an academic researcher from AstraZeneca. The author has contributed to research in topics: Innate lymphoid cell & Regeneration (biology). The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Aaron A Berlin include MedImmune.
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Papers
Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs
Jonathan S. Silver,Jennifer Kearley,Alan M. Copenhaver,Caroline Sanden,Michiko Mori,Li Yu,Gretchen Harms Pritchard,Aaron A Berlin,Christopher A. Hunter,Russell P. Bowler,Jonas S. Erjefält,Roland Kolbeck,Alison A. Humbles +12 more
TL;DR: Functional plasticity of ILC2 cells exacerbates anti-viral immunity, which may have adverse consequences in respiratory diseases such as COPD.
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Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.
Jennifer Kearley,Jonathan S. Silver,Caroline Sanden,Zheng Liu,Aaron A Berlin,Natalie White,Michiko Mori,Tuyet-Hang Pham,Christine K. Ward,Gerard J. Criner,Nathaniel Marchetti,Tomas Mustelin,Jonas S. Erjefält,Roland Kolbeck,Alison A. Humbles +14 more
TL;DR: In COPD, smoke alters the lung microenvironment to facilitate an alternative IL-33-dependent exaggerated proinflammatory response to infection, exacerbating disease.
294
IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration.
Rania Dagher,Alan M. Copenhaver,Valérie Besnard,Aaron A Berlin,Fatima Hamidi,Marielle Maret,Jingya Wang,Xiaotao Qu,Yashaswi Shrestha,Jincheng Wu,Gregory Gautier,Rajiv Raja,Michel Aubier,Roland Kolbeck,Alison A. Humbles,Marina Pretolani +15 more
TL;DR: A protective function for the IL-33-ST2 axis in bronchial epithelial repair is demonstrated, and group-2 innate lymphoid cell (ILC2)-mediated AAM activation is implicate in myeloid cell differentiation.
Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice
Christopher T. Cottage,Norman C. Peterson,Jennifer Kearley,Aaron A Berlin,Ximing Xiong,Anna Huntley,Weiguang Zhao,Charles Brown,Annik Migneault,Kamelia Zerrouki,G.J. Criner,Roland Kolbeck,Jane Connor,Raphael Lemaire +13 more
- 09 Aug 2019
TL;DR: It is suggested that targeting senescence pathways may facilitate alveolar regeneration in chronic obstructive pulmonary diseases by activating cell-proliferation signals through insulin-like growth factor 1.
PD-L1 + neutrophils contribute to injury-induced infection susceptibility.
Ajitha Thanabalasuriar,Ajitha Thanabalasuriar,Abby J. Chiang,Christopher Morehouse,Margarita Camara,Shonda Hawkins,Ashley E. Keller,Adem C. Koksal,Carolina S. Caceres,Aaron A Berlin,Nicholas Holoweckyj,Virginia N. Takahashi,Lily Cheng,Melissa de los Reyes,Mark Pelletier,Andriani C. Patera,Bret R. Sellman,Sonja Hess,Marcello Marelli,Chelsea C. Boo,Taylor S. Cohen,Antonio DiGiandomenico +21 more
TL;DR: In this article, the authors describe a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury, indicating that injury promotes changes to neutrophils that are important for wound healing but contribute to infection susceptibility.
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