Aarif M. N. Batcha
Ludwig Maximilian University of Munich
22 Papers
7 Citations
Aarif M. N. Batcha is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Myeloid leukemia & Medicine. The author has an hindex of 7, co-authored 16 publications. Previous affiliations of Aarif M. N. Batcha include German Cancer Research Center.
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Papers
Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia
Stefanos A. Bamopoulos,Stefanos A. Bamopoulos,Aarif M. N. Batcha,Vindi Jurinovic,Maja Rothenberg-Thurley,Hanna Janke,Bianka Ksienzyk,Julia Philippou-Massier,Alexander Graf,Stefan Krebs,Helmut Blum,Stephanie Schneider,Nikola P. Konstandin,Maria Cristina Sauerland,Dennis Görlich,Wolfgang E. Berdel,Bernhard J. Woermann,Stefan K. Bohlander,Stefan Canzar,Ulrich Mansmann,Wolfgang Hiddemann,Wolfgang Hiddemann,Jan Braess,Karsten Spiekermann,Karsten Spiekermann,Klaus H. Metzeler,Klaus H. Metzeler,Tobias Herold +27 more
TL;DR: It is concluded that splicing factor mutations do not represent independent prognostic markers, however, they do have genome-wide consequences on gene splicing leading to dysregulated isoform expression of several genes.
Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium
Kun Lu,Thomas Seidel,Xiaochun Cao-Ehlker,Tatjana Dorn,Aarif M. N. Batcha,Christine M. Schneider,Marie Semmler,Tilmann Volk,Alessandra Moretti,Andreas Dendorfer,Roland Tomasi +10 more
TL;DR: In this article, the authors developed a new approach for the generation of cardiac tissues based on biomimetic stimulation under application of continuously increasing stretch, which can simulate the conditions of postnatal myocardial growth.
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RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Govardhan Anande,Nandan P. Deshpande,Sylvain Mareschal,Aarif M. N. Batcha,Henry R. Hampton,Tobias Herold,Sören Lehmann,Sören Lehmann,Marc R. Wilkins,Jason W. H. Wong,Jason W. H. Wong,Ashwin Unnikrishnan,John E. Pimanda +12 more
TL;DR: This work identified aberrant alternative splicing as a molecular feature of adverse AML with clinical relevance and identified a splicing signature of four genes which refine the accuracy of existing risk prognosis schemes and validated it in a completely independent cohort.
An NGS Workflow Blueprint for DNA Sequencing Data and Its Application in Individualized Molecular Oncology.
TL;DR: A literature research is conducted and a four-stage NGS workflow is summarized for providing a systematic review on NGS-based analysis, explaining the strength and weakness of diverse N GS-based software tools, and elucidating its potential connection to individualized medicine is presented.
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Fusion gene detection by RNA sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements.
Paul Kerbs,Sebastian Vosberg,Stefan Krebs,Alexander Graf,Helmut Blum,Anja Swoboda,Aarif M. N. Batcha,Ulrich Mansmann,Dirk Metzler,Caroline A. Heckman,Tobias Herold,Philipp A. Greif +11 more
TL;DR: In this article, the authors analyzed 806 RNA-seq samples from acute myeloid leukemia (AML) patients using two state-of-the-art software tools, namely Arriba and FusionCatcher.