Aaldert Jan Elevelt
Philips
24 Papers
135 Citations
Aaldert Jan Elevelt is an academic researcher from Philips. The author has contributed to research in topics: High-intensity focused ultrasound & Controller (computing). The author has an hindex of 9, co-authored 24 publications.
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Papers
Magnetic Resonance Guided High-Intensity Focused Ultrasound Mediated Hyperthermia Improves the Intratumoral Distribution of Temperature-Sensitive Liposomal Doxorubicin
Mariska de Smet,NM Nicole Hijnen,Sander Langereis,Aaldert Jan Elevelt,Edwin Heijman,Ludwig Dubois,Ph Philippe Lambin,Holger Grüll +7 more
TL;DR: Treatment with HIFU hyperthermia not only improved the immediate drug delivery, bioavailability, and intratumoral distribution but also enhanced liposomal accumulation over time.
The magnetic susceptibility effect of gadolinium-based contrast agents on PRFS-based MR thermometry during thermal interventions
NM Nicole Hijnen,Aaldert Jan Elevelt,Jeroen A. Pikkemaat,Clemens Bos,Lambertus W. Bartels,Holger Grüll,Holger Grüll +6 more
TL;DR: The use of a paramagnetic MR contrast agent prior to MR-HIFU treatment may influence the accuracy of the PRFS MR thermometry, and compensation for the phase changes induced by the changing Gd presence is difficult.
Stability and trapping of magnetic resonance imaging contrast agents during high-intensity focused ultrasound ablation therapy.
TL;DR: Investigation of the use of Gd-DTPA shortly before magnetic resonance guided high-intensity focused ultrasound MR-HIFU thermal ablation therapy with respect to dissociation, trapping, and long-term deposition of gadolinium (Gd) in the body found no significant effect on the long- term in vivo Gd retention.
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Bone metastasis treatment using magnetic resonance-guided high intensity focused ultrasound
Sin Yuin Yeo,Aaldert Jan Elevelt,Katia Donato,Bert van Rietbergen,Natalie D. ter Hoeve,Paul J. van Diest,Holger Grüll,Holger Grüll +7 more
TL;DR: A comprehensive pre-clinical study to investigate the effects, and efficacy of MR-HIFU ablation for the palliative treatment of osteoblastic bone metastases in rats and provides fundamental data, which may motivate and advance its use in the clinical treatment of painfulBone metastases with MR- HIFU.
26
Modelling the temperature evolution of bone under high intensity focused ultrasound
ten Hmm Huub Eikelder,Dragan Bošnački,Aaldert Jan Elevelt,Katia Donato,A Di Tullio,Bjt Boris Breuer,van Jh Wijk,van Evm Edmond Dijk,Daniela Modena,Sy Sin Yuin Yeo,Holger Grüll,Holger Grüll +11 more
TL;DR: A computational model to calculate the spatial temperature evolution in bone and the adjacent tissue during sonication and includes shear waves that arise at the bone interface as well as all geometrical considerations of transducer and bone geometry.