A. Wilisch
University of Würzburg
13 Papers
126 Citations
A. Wilisch is an academic researcher from University of Würzburg. The author has contributed to research in topics: Myasthenia gravis & Thymoma. The author has an hindex of 7, co-authored 13 publications.
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Papers
•Journal Article
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis.
Alexander Marx,A. Wilisch,A. Schultz,Axel Greiner,B Magi,V. Pallini,B. Schalke,Klaus V. Toyka,Wilfried Nix,Kirchner T,Hans Konrad Müller-Hermelink +10 more
TL;DR: In thymomas with cortical differentiation many of the neoplastic epithelial cells expressed low and medium molecular weight neurofilaments detected with several antibodies, which suggests that they might autosensitize maturing T cells there and so initiate anti-titin autoimmunity in these patients.
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•Journal Article
Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas.
R Nenninger,A. Schultz,Hoffacker,M Helmreich,A. Wilisch,Bart Vandekerckhove,Thomas Hünig,B. Schalke,C Schneider,Socrates J. Tzartos,H. Kalbacher,Hk Muller-Hermelink,Alexander Marx +12 more
TL;DR: Both thymoma subtypes seem to contribute to the pathogenesis of paraneoplastic myasthenia gravis by generating naive but potentially autoaggressive T cells; in some thymomas, these cells may then be actively immunized inside the tumor.
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Characterization of the human thymic microenvironment: lymphoepithelial interaction in normal thymus and thymoma.
TL;DR: The present paper gives an overview on the cellular components and matrix molecules of the human thymic microenvironment and their development during ontogeny and suggests abnormal auto-antigen-specific positive selection of naive T cells as the essential molecular mechanism by which thymomas contribute to the autoimmunization against the acetylcholine receptor and other muscle proteins.
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Titin Epitope in Thymoma
A. Wilisch,A. Schultz,A. Jung,T. Kirchner,B. Schalke,K.V. Toyka,V. Pallini,Socrates J. Tzartos,Hans Konrad Müller-Hermelink,Alexander Marx +9 more
- 01 Jan 1997
TL;DR: This study reports, that a monoclonal antibody directed against the “Very Immunogenic Cytoplasmic Region” of the acetylcholine receptor crossreacts with a 153 kD molecule only in cortical type thymomas, and suggests that one molecule, NF-M, which does contain titin and AChR epitopes, might autosensitize maturing T-cells and initiate autoimmunity in patients with paraneoplastic MG.
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Low Levels of Acetylcholine Receptor Delta-Subunit Message and Protein in Human Thymus Suggests the Occurrence of ‘Triplet Receptors’ in Thymic Myoid Cells
Alexander Marx,A. Wilisch,Stefanie Gutsche,Viola Hoffacker,A. Schultz,Socrates J. Tzartos,Wilfried Nix,Berthold Schalke,Christiane Schneider,Hans Konrad Müller-Hermelink +9 more
- 01 Jan 2000
TL;DR: The muscular AChR is a pentameric ion channel composed of 4 different subunits and the α-subunit contains the main epitopes recognized by MG autoantibodies.
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