7 Papers
125 Citations
A Wakkach is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Myasthenia gravis & Cell culture. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of A Wakkach include International Practical Shooting Confederation.
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Papers
Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles. Evidences for a compensatory mechanism triggered by receptor loss.
T Guyon,A Wakkach,Sandrine Poea,Vincent Mouly,Isabelle Klingel-Schmitt,Philippe Levasseur,David Beeson,O Asher,Socrates J. Tzartos,Sonia Berrih-Aknin +9 more
TL;DR: The existence of a compensatory mechanism regulating the expression of the genes coding for the adult nAChR in patients with MG is demonstrated, suggesting theexistence of a new muscular signaling pathway system coupled to nA ChR internalization and independent of muscle electrical activity.
Thymic myoid cells express high levels of muscle genes.
TL;DR: Since myoid cells express high level of most muscle genes and are consistently found in the thymic medulla, they may contribute to the mechanisms involved in the induction and maintenance of immune tolerance.
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Establishment of a Human Thymic Myoid Cell Line : Phenotypic and Functional Characteristics
A Wakkach,Sandrine Poea,Eric Chastre,Christian Gespach,Florence Lecerf,Sabine De La Porte,Socrates J. Tzartos,Alain Coulombe,Sonia Berrih-Aknin +8 more
TL;DR: The immortalization of stromal cells from human thymus by using a plasmid vector encoding the SV40 T oncogene resulted in a new line of myoid cells that expressed both the fetal and adult forms of muscle acetylcholine receptor (AChR) at the mRNA level, as well as the myogenic transcription factor MyoD1.
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•Journal Article
Functional Expression of Receptors for Calcitonin Gene-Related Peptide, Calcitonin, and Vasoactive Intestinal Peptide in the Human Thymus and Thymomas from Myasthenia Gravis Patients
Julien C. Marie,A Wakkach,Anne Marie Coudray,Eric Chastre,Sonia Berrih-Aknin,Christian Gespach +5 more
TL;DR: The data suggest that the neuroendocrine peptides VIP, CGRP, and CT may exert functional roles during MG and malignant transformation of the human thymus.
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