Background An elevated homocysteine level is associated with an increased risk for developing atherosclerosis, which can in turn lead to coronary artery disease (CAD). The risk of cardiovascular events in patients with hyperhomocysteinemia increases more than 3-fold. Systemic lupus erythematosus (SLE) is characterized by early and accelerated atherosclerosis developed due to autoimmune inflammation. Intima-media thickness (IMT) of the common carotid artery (CCA) is associated with subclinical atherosclerosis and can reflect coronary damage. Objectives The aim of our study was to determine the presence of hyperhomocysteine and its association with cytokines, inflammatory markers in patients with SLE. Methods We examined 24 female patients with SLE (mean age 41,50 (31,50; 50,50) years old) and with subclinical atherosclerosis revealed ultrasonographically. The comparison group included 22 patients with CAD and the history of myocardial infarction (MI) developed at the mean age of 49,0 (45,0;51,0) years old. We assessed the presence of traditional risk factors. The levels of homocysteine, high sensitive C- reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor - α (TNF-α) were determined with ELISA. Results The IMT CCA and the presence of atherosclerotic plaques were not statistically different both in the patients with SLE and these with CAD. Frequency of occurrence of risk factors (smoking, obesity, physical inactivity, arterial hypertension, family history of early MI, high levels of total cholesterol, LDL cholesterol, and low levels of HDL cholesterol) was not statistically different in both the groups. Hyperhomocysteinemia was identified in 58,33% patients with SLE and in 22,73% patients with CAD and was more pronounced in the first group (χ 2 =6,0; p=0,014). The levels of homocysteine were higher in patients with SLE than with CAD (p=0,033). We revealed high positive correlation between elevated levels of homocysteine and TNF-α in SLE patients (p=0,040). The levels of TNF-α and IL-6 were higher in patients with SLE than with CAD (p=0,001 and p=0,015, respectively). The frequency of high levels of IL-6 was higher in SLE patients than in the other group (p=0,041). Frequency of occurrence of elevated levels of hs-CRP and fibrinogen, as well as their levels were not statistically different in both the groups. Conclusions These data confirm that the early carotid atherosclerosis in patients with SLE may be a predictor of coronary artery lesions as well as in patients with CAD. Inflammatory process, elevated levels of homocysteine, proinflammatory cytokines (IL-6, TNF-α) are associated with early atherosclerosis in patients with SLE as a result of autoimmune inflammation. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.3839

https://ard.bmj.com/content/annrheumdis/73/Suppl_2/984.2.full.pdf

AB0538 Association of Homocysteine and Inflammatory Markers with Early Atherosclerosis in Patients with Systemic Lupus Erythematosus

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

A.V. Kundzer

Author Tools

Chat about Author

Papers

AB0538 Association of Homocysteine and Inflammatory Markers with Early Atherosclerosis in Patients with Systemic Lupus Erythematosus