26 Papers
135 Citations
A. V. Kachko is an academic researcher from State Research Center of Virology and Biotechnology VECTOR. The author has contributed to research in topics: Epitope & Monoclonal antibody. The author has an hindex of 8, co-authored 25 publications.
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Papers
Amino Acid Residue-Specific Neutralization and Nonneutralization of Hepatitis C Virus by Monoclonal Antibodies to the E2 Protein
Hongying Duan,A. V. Kachko,Lilin Zhong,Evi Struble,Shivani Pandey,Hailing Yan,Christine Harman,Maria Luisa Virata-Theimer,Lu Deng,Zhong Zhao,Marian E. Major,Stephen M. Feinstone,Pei Zhang +12 more
TL;DR: The data suggest that the effectiveness of antibody-mediated neutralization of HCV could be deduced from the interplay between an antibody and a specific set of amino acid residues, which should provide insights for designing a vaccine to control HCV infection in vivo.
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Induction of Alternatively Spliced Spermidine/Spermine N1-Acetyltransferase mRNA in the Human Kidney Cells Infected by Venezuelan Equine Encephalitis and Tick-Borne Encephalitis Viruses
Natalia N. Nikiforova,Tatyana V. Velikodvorskaja,A. V. Kachko,Lev G. Nikolaev,Galina S. Monastyrskaya,Sergey Lukyanov,S. N. Konovalova,Elena V. Protopopova,V. A. Svyatchenko,N. N. Kiselev,Valery B. Loktev,Eugene D. Sverdlov +11 more
TL;DR: This first evidence of the host gene alternatively spliced mRNA induction by RNA viruses raises the questions of its biological role, regulation mechanisms of alternative splicing, and significance for the virus life cycle.
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Human laminin binding protein as a cell receptor for the tick-borne encephalitis virus
Elena V. Protopopova,Aleksandr V. Sorokin,S. N. Konovalova,A. V. Kachko,Sergey V. Netesov,Valery B. Loktev +5 more
TL;DR: An approach to obtain the cell receptor for the tick-borne encephalitis (TBE) virus by affinity chromatography using polyclonal antiidiotyping antibodies (AlAbs) as antireceptor antibodies as well as a gene-engineering product of the recombinant laminin binding protein was developed.
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Characterization of glycoprotein E C-End of West Nile virus and evaluation of its interaction force with αVβ3 integrin as putative cellular receptor
Maria V. Bogachek,B. N. Zaitsev,Sergey K. Sekatskii,Elena V. Protopopova,Vladimir A. Ternovoi,A. V. Ivanova,A. V. Kachko,V. A. Ivanisenko,Giovanni Dietler,Valery B. Loktev +9 more
TL;DR: It is proposed that WNV gpE can interact specifically with two cellular proteins (LBP and αVβ3 integrin) during virus entry.
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Neutralizing monoclonal antibodies against Russian strain of the West Nile virus.
Ivan A. Razumov,Kazachinskaia Ei,Vladimir A. Ternovoi,Elena V. Protopopova,Irina V. Galkina,Valentin L. Gromashevskii,Alexander G. Prilipov,A. V. Kachko,A. V. Ivanova,Dimitry K. L'vov,Valery B. Loktev +10 more
TL;DR: At least 13 different Nt-epitopes for WNV are suggested, with two discrete regions of protein E involved in neutralization of WNV.
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