A Tomasz
Rockefeller University
59 Papers
2K Citations
A Tomasz is an academic researcher from Rockefeller University. The author has contributed to research in topics: Peptidoglycan & Cell wall. The author has an hindex of 41, co-authored 59 publications.
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Papers
Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci.
A Tomasz,Sharon Nachman,H Leaf +2 more
TL;DR: It is suggested that these classes represent stages in an evolutionary sequence leading to progressively improved phenotypic expression of methicillin resistance in staphylococci.
312
Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus.
Krzysztof Sieradzki,A Tomasz +1 more
TL;DR: A vancomycin-resistant mutant of Staphylococcus aureus (VM) continued to grow and synthesize peptidoglycan in the presence of vancomynet (50 microg/ml) in the medium, but the antibiotic completely inhibited cell wall turnover and autolysis, resulting in the accumulation of cell wall material at the cell surface and inhibition of daughter cell separation as mentioned in this paper.
284
Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing.
TL;DR: A gene cluster located on the chromosomal SmaI I fragment of a highly methicillin resistant strain of Staphylococcus aureus, consisting of four open reading frames (ORFs), showed close similarities to the Bacillus subtilis sigB operon both in overall organization and in primary sequences of the gene products.
258
Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus.
H. de Lencastre,A Tomasz +1 more
TL;DR: A new transposon library constructed in the background of the highly and homogeneously methicillin-resistant Staphylococcus aureus strain COL yielded 70 independent insertional mutants with reduced levels of antibiotic resistance.
211
Spread and maintenance of a dominant methicillin-resistant Staphylococcus aureus (MRSA) clone during an outbreak of MRSA disease in a Spanish hospital.
TL;DR: A single MRSA clone belonging to ClaI type I, pulsed-field gel electrophoretic pattern B, and Tn554 pattern a was responsible for the great majority of infections and appeared at the very beginning of the outbreak, spread throughout the hospital wards, and was also carried by inpatients and health-care workers and on environmental surfaces.
203