Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium.

Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity - A review.

A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+

Biochar has attracted recent research interest as a metal adsorbent. The heavy metal adsorption capacity of biochar can be controlled by the carbonization of biochar. The adsorption characteristics of heavy metals (Pb, Cu, and Cd) by peat moss-derived biochars produced under different carbonization conditions were investigated by a series of batch experiments. Biochars were produced by the pyrolysis of peat moss over a temperature range of 400–1000 °C for 30–90 min. Biochar produced at 800 °C for 90 min was the most efficient for the removal of Pb and Cu, when weight loss ratio was considered. The pseudo-second-order and Langmuir models adequately described kinetics and isotherms, respectively, of heavy metal adsorption on peat moss-derived biochar, indicating that heavy metal ions were chemically adsorbed on the adsorption sites as uniform monolayer. The peat moss-derived biochar showed the highest maximum adsorption capacity for Pb (81.3 mg/g), followed by Cd and Cu, which were 39.8 and 18.2 mg/g, respectively. This study shows that peat moss-derived biochar is an effective adsorbent to remediate heavy metal-contaminated water.

/pdf/comparison-of-heavy-metal-adsorption-by-peat-moss-and-peat-volchbalf3.pdf

Comparison of Heavy Metal Adsorption by Peat Moss and Peat Moss-Derived Biochar Produced Under Different Carbonization Conditions

Cadmium-dependent enzyme activity alteration is not imputable to lipid peroxidation.

The toxic effects of cadmium, mercury, and copper were compared over the over range 0.01, 0.03, and 0.1 mM using the isolated perfused rat liver preparation. All metals caused similar changes in various parameters used to describe general toxicity. Thus reductions in oxygen consumption, perfusion flow, and biliary secretion were found, while lactate dehydrogenase release into the perfusate, as well as liver weight, increased also in a dose-dependent fashion. Each metal caused similar magnitudes of changes and exerted similar potency. Measurement of other parameters indicating more specific injury revealed a number of differences. Although all metals reduced hepatic ATP concentration, mercury and cadmium were more potent than copper in this respect. Cadmium was the most potent at decreasing reduced glutathione levels. Mercury was most effective at increasing tissue calcium content, while copper was less so, and cadmium ineffective. Only copper significantly increased tissue malondialdehyde (MDA) content, while all metals increased its release into perfusate. Furthermore, whereas cadmium seemed the most potent metal in increasing MDA release, it was least efficacious, while copper was the most. Antioxidants such as superoxide dismutase, catalase, and Trolox C only reduced cadmium's influence on MDA in perfusate; however, they did not affect cadmium's ability to alter most other parameters of vitality. Albumin reversed the toxic effects of copper and mercury, but not cadmium. While metal-induced reductions in perfusion flow accounted for some of the toxic effects of the metals investigated, the results as a whole supported the suggestion that all metals exerted toxicity at the mitochondria, since ATP levels were reduced in a manner that could not be reproduced by perfusion flow reduction alone. Lipid peroxidation appears to play little role in determining toxicity induced by any of these metals. Furthermore, albumin may play an important physiological role in preventing hepatic injury that might otherwise be induced through acute metal intoxication.

Comparative studies on the toxicity of mercury, cadmium, and copper toward the isolated perfused rat liver.

Aims This study extends the limited research on predictors of completion of adolescent residential drug and alcohol program.Design and Methods A Queensland, Australia, five-bed state-wide voluntary adolescent drug and alcohol withdrawal service collected routine clinical pre-entry data over a period of 9 years (2000–2009) on 524 subjects. Potential predictors of program completion included socio-demographic, family functioning, past mental health history, mental health problems on admission, and patterns of drug use variables. The chi-square analysis identified significant predictors with subsequent multivariate logistic regression modeling. Given the loss of data, additional multiple imputation logistic regression analysis was utilized.Results Initial predictors were aged 17 and over; a past history of psychiatric treatment or violence or assault; mental health problems identified on entry; absence of current alcohol use or ecstasy use. After regression and multiple imputation modeling, predictors were a history of psychiatric treatment and of violence/assault.Discussion and Conclusions A history of co-morbidity rather than traditional markers of good outcomes such as sex, ethnic background, income support, and housing support predicted program retention. The study reinforces the important role of non-substance psychiatry co-morbidity in the treatment of substance use disorder. 

Predictors of completion of an adolescent residential alcohol and other drug withdrawal program

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Comparative studies on the toxicity of mercury, cadmium, and copper toward the isolated perfused rat liver.

Predictors of completion of an adolescent residential alcohol and other drug withdrawal program