A Sanfridson
Howard Hughes Medical Institute
5 Papers
A Sanfridson is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cancer & Internal medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Variant screening of PYY3-36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity.
Søren Østergaard,Carsten Jessen,J. Paulsson,Marina A. Kasimova,Kilian Conde-Frieboes,Ellen Marie Straarup,R. B. Skyggebjerg,Lars Ynddal,A Sanfridson,Birgitte Schjellerup Wulff,A. P. Chambers +10 more
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145 Nadunolimab inhibits IL-1α/β-induced CXCR1/2 ligand expression and reduces serum levels of CXCL1 and CXCL5 in NSCLC and PDAC patients
Camilla Rydberg Millrud,Elin Jaensson Gyllenbäck,Petter Skoog,A Sanfridson,David Liberg +4 more
- 01 Nov 2022
TL;DR: Nadunolimab as mentioned in this paper is a fully humanized ADCCenhanced monoclo-nal IgG1 antibody targeting IL1RAP and disrupting both IL-1 a and IL1 b signaling.
Safety, efficacy and biomarker data in patients with non-small cell lung cancer treated with the anti-IL1RAP antibody nadunolimab in combination with platinum doublet.
Luis Paz-Ares,A Paulus,Marius Zemaitis,Saulius Cicenas,Zanete Zvirbule,Enriqueta Felip,A Sanfridson,Camilla Rydberg-Millrud,Susanne Magnusson,Nedjad Losic,Ignacio Garcia-Ribas +10 more
TL;DR: In this paper , a clinical phase 1/2 trial was conducted in non-small cell lung cancer (NSCLC) patients with nadunolimab and platinum doublet.
Abstract 2172: Tumor IL1RAP levels and reduction in serum biomarkers correlate with response in PDAC patients treated with nadunolimab, an anti-IL1RAP monoclonal antibody, in combination with gemcitabine and nab-paclitaxel
Eric Van Cutsem,Joëlle Collignon,Rikke Løvendahl Eefsen,Sebastian Ochsenreither,Zanete Zvirbule,Audrius Ivanauskas,Camilla Rydberg Millrud,Petter Skoog,Nedjad Losic,Susanne Magnusson,A Sanfridson,David Liberg +11 more
TL;DR: Van Cutsem et al. as discussed by the authors showed a relationship between high IL1RAP expression on tumor and stromal cells in all biopsies analyzed and IL 1RAP-positive infiltrating immune cells were detected in biopsy from 94% of patients (n=38).
Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.
TL;DR: It is hypothesized that downregulation of cell-surface CD4 by Nef facilitates the efficient release of infectious progeny virions and, hence, viral spread in vivo.