A. Sakmann
University of Hamburg
10 Papers
76 Citations
A. Sakmann is an academic researcher from University of Hamburg. The author has contributed to research in topics: Tableting & Excipient. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of A. Sakmann include University of Tübingen.
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Papers
Suitability of various excipients as carrier and coating materials for liquisolid compacts
TL;DR: Investigation of the suitability of various novel tableting excipients as carrier and coating materials for liquisolid compacts found Fujicalin® and especially Neusilin® are more effective carrier materials for liquid adsorption than Avicel®, which is often used for liqu isolid systems.
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Enhancement of griseofulvin release from liquisolid compacts
TL;DR: It could be shown that Neusilin® with its sevenfold higher liquid adsorption capacity than the commonly used Avicel® and Aerosil® allows the production of liquisolid formulations with lower tablet weights.
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Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding
Sönke Rehder,Marten Klukkert,Korbinian Löbmann,Clare J. Strachan,A. Sakmann,Keith C. Gordon,Thomas Rades,Claudia S. Leopold +7 more
TL;DR: It was shown that liquid-assisted grinding led to faster cocrystal formation than dry grinding, which may be explained by the higher transformation rate due to the presence of liquid.
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Comparison of traditional and novel tableting excipients: physical and compaction properties.
TL;DR: Comparing two traditionally used and two novel tableting excipients with regard to their physical and tableting properties as well as their magnesium stearate sensitivity confirmed the plastic deformation behavior of microcrystalline cellulose and the brittle fracture of anhydrous dicalcium phosphate.
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Thermal degradation of amorphous glibenclamide.
TL;DR: The crystals formed during sublimation of amorphous glibenclamide do not represent a glibanclamide polymorph, but a thermal degradation product, namely 1,3-dicyclohexylurea, which may decompose to carbon monoxide and cyclohexylamine.
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