5 Papers
125 Citations
A. Rotter is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Muscarinic acetylcholine receptor & Hypoglossal nucleus. The author has an hindex of 4, co-authored 5 publications.
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Papers
Muscarinic receptors in the central nervous system of the rat. II. Distribution of binding of [3H]propylbenzilylcholine mustard in the midbrain and hindbrain
TL;DR: The distribution of muscarinic receptors has been studied in the rat midbrain and hindbrain by counting silver grains in light microscope autoradiographs of the specific (atropine-sensitive) binding of [3H]propylbenzilylcholine mustard in cryostat sections.
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Muscarinic receptors in the central nervous system of the rat. IV. A comparison of the effects of axotomy and deafferentation on the binding of [3H]propylbenzilylcholine mustard and associated synaptic changes in the hypoglossal and pontine nuclei.
TL;DR: Later, both muscarinic ligand binding and synapse numbers recover to an extent which depends at least in part on the effectiveness of the peripheral nerve regeneration, suggesting that both the receptor and synapses changes may be dependent upon neuromuscular contacts.
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Axotomy causes loss of muscarinic receptors and loss of synaptic contacts in the hypoglossal nucleus
TL;DR: It is reported here, however, that in the brain stem the hypoglossal nuclei are heavily labelled with 3H-PrBCM, a potent irreversible muscarinic antagonist the binding of which to rat brain sections can be demonstrated autoradiographically.
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Muscarinic receptors in the central nervous system of the rat. I. Technique for autoradiographic localization of the binding of [3H]propylbenzilylcholine mustard and its distribution in the forebrain.
TL;DR: Binding was unaffected by drugs acting at nicotinic receptors, or by physostigmine, but was inhibited by muscarinic drugs (pilocarpine, oxotremorine, 3-quinuclidinylbenzilate).