A. Robles
Loma Linda University
7 Papers
18 Citations
A. Robles is an academic researcher from Loma Linda University. The author has contributed to research in topics: Porphyromonas gingivalis & Mutant. The author has an hindex of 6, co-authored 7 publications.
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Papers
VimA mediates multiple functions that control virulence in Porphyromonas gingivalis
TL;DR: It is postulated that the multifunction of VimA is modulated via a post-translational mechanism involving acetylation, which may be involved in protein sorting and transport in P. gingivalis.
Porphyromonas gingivalis mutY is involved in the repair of oxidative stress-induced DNA mispairing.
TL;DR: The P. gingivalis MutY homologue was insertionally inactivated using the ermF-ermAM antibiotic cassette and used to create a mutY-deficient mutant (FLL147) by allelic exchange mutagenesis, which had an increased rate of spontaneous mutation and was more sensitive to hydrogen peroxide compared with the wild-type W83 strain.
In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
TL;DR: Results suggest the VimF glycoprotein is a galactosyltransferase that may be specific for gingipain glycosylation, and galatose is vital for the growing glycan chain.
Life in a diverse oral community – Strategies for oxidative stress survival
Leroy G. Henry,Marie-Claire Boutrin,A. Wilson Aruni,A. Robles,Alexia Ximinies,Hansel M. Fletcher +5 more
TL;DR: The combination of these multifaceted strategies would provide a comprehensive defense and support system against the repetitive host immune response to promote microbial persistence and disease.
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The roles of RgpB and Kgp in late onset gingipain activity in the vimA-defective mutant of Porphyromonas gingivalis W83.
Yuetan Dou,A. Robles,Francis Roy,A.W. Aruni,Lawrence B. Sandberg,E. Nothnagel,Hansel M. Fletcher,Hansel M. Fletcher +7 more
TL;DR: The results suggest multiple gingipain activation pathways in P. gingivalis, which is VimA-dependent, the maturation/activation pathways for RgpB and Kgp are interdependent in the absence VimA.