A. R. Sharrett
Johns Hopkins University
15 Papers
17 Citations
A. R. Sharrett is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 15 publications. Previous affiliations of A. R. Sharrett include University of North Carolina at Chapel Hill.
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Papers
Retinal microvascular abnormalities and blood pressure in older people: the Cardiovascular Health Study
Tien Yin Wong,Larry D. Hubbard,Ronald Klein,Emily K Marino,Richard A. Kronmal,A. R. Sharrett,David S. Siscovick,Gregory L. Burke,James M. Tielsch +8 more
TL;DR: The data suggest that retinal microvascular changes reflect severity and duration of hypertension, and generalised retinal arteriolar narrowing and possibly arteriovenous nicking are related to previously elevated blood pressure, independent of concurrent blood pressure.
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Vascular risk factors and longitudinal changes on brain MRI: The ARIC study
David S. Knopman,Alan D. Penman,Diane J. Catellier,Laura H. Coker,Dean Shibata,A. R. Sharrett,Thomas H. Mosley +6 more
TL;DR: Both atrophic and ischemic imaging changes were driven by altered glycemic and blood pressure control beginning in midlife.
Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study
Alvaro Alonso,Thomas H. Mosley,R. F. Gottesman,Diane J. Catellier,A. R. Sharrett,Josef Coresh +5 more
TL;DR: Smoking, hypertension and diabetes were strongly associated with subsequent risk of hospitalisation with dementia, particularly in middle-aged individuals, and the importance of early lifestyle modification and risk factor treatment to prevent dementia is emphasised.
Retinal microvascular abnormalities and cognitive decline: The ARIC 14-year follow-up study
S. R. Lesage,Thomas H. Mosley,Tien Yin Wong,Moyses Szklo,D. S. Knopman,Diane J. Catellier,Stephen R. Cole,Ronald Klein,Josef Coresh,Laura H. Coker,A. R. Sharrett +10 more
TL;DR: Signs of retinal vascular changes, as markers of the cerebral microvasculature, are associated with declines in executive function and psychomotor speed, adding to the growing evidence for the role of microvascular disease in cognitive decline in the elderly.
Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
Daniel C. Bezerra,Daniel C. Bezerra,A. R. Sharrett,Kuni Matsushita,R. F. Gottesman,Dean Shibata,Thomas H. Mosley,Josef Coresh,Moyses Szklo,Marilia Sá Carvalho,Elizabeth Selvin +10 more
TL;DR: Smaller lacunes (even those <3 mm) were associated with diabetes and HbA1c, and larger lacunes associated with LDL cholesterol, differences which support long-held theories relating to their underlying pathology.