Abortion is still a problem that receives special attention because based on data from the World Health Organization (WHO), abortion accounts for 15-50% of the causes of maternal death in the world. One of the risk factors for abortion is infection during pregnancy, including toxoplasmosis. The aim of this study was to analyze whether there was a relationship between toxoplasma IgG avidity levels and the risk of abortion. The research uses a literature review study to identify, analyze, and evaluate scientific papers through MDPI, PubMed, and ScienceDirect data sources. 60 articles were produced from the four data sources, there were 7 articles that passed the inclusion criteria which are summarized in the PRISMA diagram. The results in one article mentioned two abortions and the other article mentioned 17 abortions, both in first trimester pregnant women with low toxoplasma IgG avidity levels. Both articles show the results that women who have low toxoplasma IgG avidity levels experience more abortions in the early trimester than women who have medium or high toxoplasma IgG avidity levels. The conclusion of this study was that there was a relationship between toxoplasma IgG avidity levels and the risk of abortion.

Relationship between toxoplasma IgG avidity levels and abortion risk

This study assessed the seroprevalence of Toxoplasma gondii and risk factors among 428 pregnant women attending Basic Health Units (BHUs) in Araçatuba, São Paulo, Brazil. The seroprevalence was 55.14%, indicating high exposure to the parasite in this population. Using a multi-level logistic regression model, this study analyzed these predictors to determine their association with a higher seropositivity rate, with BHUs included as a random factor. Predictors associated with higher seropositivity included older age (36–45 years), with a 71.64% prevalence in this group, and multiparity (61.65%). Women with lower educational levels were also more likely to be infected, with 59.46% seropositivity recorded among those who had only completed elementary school. Despite identifying several risk factors, no significant correlation was found between undercooked meat consumption or contact with soil and infection. These findings highlight the need for targeted public health interventions, particularly for educating high-risk groups about toxoplasmosis prevention, such as safe food handling and avoiding raw dairy products. Additionally, BHUs play a critical role in early detection and prevention. These units are important for providing healthcare access and preventive education for vulnerable populations. Given the high seroprevalence, this study underscores the urgency of implementing prenatal screening and educational programs to reduce the risks of congenital toxoplasmosis in this region. 

Seroprevalence of Toxoplasma gondii and Associated Risk Factors in Pregnant Women in Araçatuba, São Paulo, Brazil: A Multi-Level Analysis

TORCH enfeksiyonları, Toxoplasma gondii, Rubella, Sitomegalovirus (CMV), Herpes simpleks virüs ve diğer bazı patojenlerin neden olduğu, anne-fetal bariyeri geçebilen ve potansiyel olarak fetüsün gelişimini olumsuz etkileyebilen bir grup enfeksiyonu ifade etmektedir. Bu çalışmada, doğurganlık çağındaki kadınlarda konjenital enfeksiyonlara neden olma potansiyeline sahip Toksoplazma, Rubella ve CMV’ye karşı oluşan antikorların seroprevalansının belirlenmesi amaçlanmıştır. 1 Ocak 2020 ve 1 Aralık 2022 tarihleri arasında laboratuvarımıza anti-Toksoplazma IgM ve IgG, anti-Rubella IgM ve IgG, anti-CMV IgM ve IgG serolojisinin araştırılması amacı ile gönderilen doğurganlık çağındaki 15–49 yaş arası toplam 2155 kadına ait test sonuçları retrospektif olarak incelenmiştir. Hasta serumlarında, IgM ve IgG antikorları Enzyme Linked Fluorescent Assay (ELFA-VIDAS, bioMérieux, Fransa) yöntemi ile tespit edilmiştir. Çalışmamızda anti-Toksoplazma IgM pozitifliği %0,5, anti-Toksoplazma IgG pozitifliği %19,4; anti-Rubella IgM pozitifliği %0,5, anti-Rubella IgG pozitifliği %92,3; anti-CMV IgM pozitifliği %0,5, anti-CMV IgG pozitifliği ise %99,9 olarak tespit edilmiştir. Toksoplazma IgG seropozitifliği ile yaş grubu arasında istatistiksel olarak anlamlı bir farklılık olduğu ve yaşın azalması ile istatistiksel olarak arttığı tespit edilmiştir (p 

pdf/seroprevalence-of-toxoplasma-rubella-and-cytomegalovirus-3yf6hzmsoa.pdf

Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus Infections in Women of Childbearing Age Admitted to Kafkas University Health Research and Application Hospital: A Three-Year Evaluation

Evaluation of Toxoplasma gondii, Rubella, and CMV Antibody Positivity and Avidity Test Results in Female Patients Admitted to A State Hospital in İstanbul

Toxoplasmosis, caused by the obligate intracellular protozoan parasite Toxoplasma gondii (T. gondii), is a globally prevalent zoonotic disease with potentially severe implications for immunocompromised individuals, pregnant women, and their fetuses/children. This study examined the prevalence of anti-T. gondii IgM and IgG antibodies in two groups of childbearing age women, including 653 participants in Group 1 (2013-2016) and 3221 participants in Group 2 (2019-2022). Our results revealed a decrease in the overall positivity rate of anti-T. gondii IgM antibodies from 2.32% to 1.06%, suggesting improved public health interventions over time. However, there were variations among different age groups and between rural and urban environments, with a significant decrease in urban areas across all age groups from Group 1 to Group 2. Regarding anti-T. gondii IgG antibodies, we did not observe a significant change in the seropositivity rate between the two groups. In the rural population with an age group over 35 years, we observed the highest positivity rate in Group 2. This study provided information on the risk factors and burden of toxoplasmosis in women of childbearing age with data that can be valuable to public health policies and the planning of healthcare measures for effective toxoplasmosis management. 

Toxoplasma gondii Seroprevalence and Trends in Women Presenting for Toxoplasma Screening in South-West Romania

Maternal-fetal infectious pathology-notably the TORCH panel (Toxoplasma gondii, rubella, Cytomegalovirus, and herpes simplex viruses)-critically impacts maternal and neonatal health. This review collates data on the seroprevalence of IgG and IgM antibodies against TORCH agents in Romanian women, aiming to discern regional and population differences and identify risk factors. Twenty studies were included in the review, revealing variable seroprevalence rates across the country. Regions such as Moldavia and Banat showed higher anti-T. gondii IgG seroprevalence rates than Bihor, with notable declines in Banat. Rural, older, and multiparous women showed elevated T. gondii IgG rates. Anti-rubella vaccine introduction significantly reduced the prevalence of anti-rubella IgG antibodies, but recent vaccination coverage decreases raise concerns. CMV and HSV seroprevalence varied geographically, with rural areas generally showing higher CMV rates and HSV influenced by factors like education level and number of sexual partners. Concurrent seroprevalence of multiple TORCH components in some cases underscores potential common risk factors. This study highlights the importance of continuous monitoring and preventive measures such as vaccinations and awareness campaigns to mitigate the health impact on the pregnant population. 

Seroprevalence of Infections with TORCH Agents in Romania: A Systematic Review

Sepsis is the body’s unregulated response to infection and if not properly managed it can lead to septic shock, multiple organ failure and death.

The aim of this article is to present a case of aortic periprosthetic infection, diagnosed in the Infectious Diseases Department of the Hospital no. 3 from Craiova, Romania. Abdominal aortic aneurysm is a serious medical condition, with a high risk of death due to the rupture of the arterial wall. The early antimicrobial treatment decreased the inflammatory markers level Although antibiotic therapy was initiated early, due to multiple associated pathologies, the patient died.

/pdf/clinical-case-of-a-patient-with-aortic-periprosthetic-1ia16ib3.pdf

Clinical Case of a Patient With Aortic Periprosthetic Infection

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Toxoplasma gondii Seroprevalence and Trends in Women Presenting for Toxoplasma Screening in South-West Romania

Seroprevalence of Infections with TORCH Agents in Romania: A Systematic Review

Clinical Case of a Patient With Aortic Periprosthetic Infection