23 Papers
384 Citations
A Klier is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Operon & Gene. The author has an hindex of 19, co-authored 23 publications.
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Papers
Signal transduction pathway controlling synthesis of a class of degradative enzymes in Bacillus subtilis: expression of the regulatory genes and analysis of mutations in degS and degU
TL;DR: The expression of degQ was shown to be subject both to catabolite repression and DegS-DegU-mediated control, allowing an increase in the rate of synthesis of degZ under conditions of nitrogen starvation, consistent with the hypothesis that this control system responds to an environmental signal such as limitations of nitrogen, carbon, or phosphate sources.
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The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus.
TL;DR: It is shown that mutations in either arlR or arlS increase the production of secreted proteins, and the results suggest that the Arl system interacts with both agr and sarA regulatory loci to modulate the virulence regulation network.
254
Induction of the Bacillus subtilis ptsGHI operon by glucose is controlled by a novel antiterminator, GlcT.
Jörg Stülke,Isabelle Martin-Verstraete,Monique Zagorec,Matthias Rose,A Klier,Georges Rapoport +5 more
TL;DR: It is shown that these three genes (ptsG, ptsH, and ptsI) form an operon, the expression of which is inducible by glucose, and that expression of this operon is subject to negative autoregulation by the glucose permease, which is the ptsG gene product.
203
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon
TL;DR: The levanase gene (sacC) of Bacillus subtilis is the distal gene of a fructose-inducible operon containing five genes and the complete nucleotide sequence of this operon was determined and four regulatory mutations leading to constitutive expression of the lavanase operon were mapped using recombination experiments.
154
Two different mechanisms mediate catabolite repression of the Bacillus subtilis levanase operon.
TL;DR: It is shown that this CcpA-independent pathway required the presence of the domain of LevR homologous to the BglG family of bacterial antiterminators, and was partially resistant to catabolite repression in both mutants.
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