6 Papers
9 Citations
A. Kim is an academic researcher from University of Maryland, Baltimore County. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 3 publications.
Chat about Author
Papers
Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting.
Jamil S. Saad,Sherimay D. Ablan,Ruba H. Ghanam,A. Kim,Kalola Andrews,Kunio Nagashima,Ferri Soheilian,Eric O. Freed,Michael F. Summers +8 more
TL;DR: It is indicated that HIV-1 and HIV-2 are both targeted to the plasma membrane for assembly via a PI(4,5)P(2)-dependent mechanism, despite differences in the sensitivity of the MA myristyl switch, and a potential mechanism that may contribute to the poor replication kinetics of HIV- 2 is suggested.
100
Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch
Jamil S. Saad,A. Kim,Ruba H. Ghanam,Amanda K. Dalton,Volker M. Vogt,Zhibin Wu,Wuyuan Lu,Michael F. Summers +7 more
TL;DR: The hypothesis that phosphorylation is unlikely to significantly influence membrane‐mediated intracellular trafficking is supported by the findings of these studies.
KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells
Sofija Vlasevska,Laura Garcia-Ibanez,Romain Duval,Antony B. Holmes,Rahat Jahan,Bowen Cai,A. Kim,Tongwei Mo,Katia Basso,Rajesh K. Soni,Govind Bhagat,Riccardo Dalla-Favera,Laura Pasqualucci +12 more
TL;DR: In this article , the authors provide a mechanistic explanation to the frequent coselection of inactivating CREBBP and KMT2D mutations in lymphoma, revealing a biochemical and functional cooperativity at select enhancer networks whose disruption facilitates the preneoplastic expansion of germinal center B cells.
8
Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
James W. Saville,Dhiraj Mannar,Xing Zhu,Shanti S. Srivastava,Alison M. Berezuk,Jean-Philippe Demers,Steven Zhou,Katharine Tuttle,Inna Sekirov,A. Kim,Wei Liu,Dimiter S. Dimitrov,Sriram Subramaniam +12 more
TL;DR: In this paper , structural and biochemical aspects of SARS-CoV-2 were assessed using cryo-electron microscopy (cryo-EM), ACE2-binding and antibody neutralization analyses.
Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains
Chun Chen,James W. Saville,Michelle Marti,Alexandra Schäfer,Mary Hongying Cheng,Dhiraj Mannar,Xing Zhu,Alison M. Berezuk,Anupam Banerjee,Michele D. Sobolewski,A. Kim,Benjamin R. Treat,Priscila Mayrelle da Silva Castanha,Nathan Enick,Kevin McCormick,Xianglei Liu,Cynthia Adams,M. G. Hines,Zehua Sun,Weizao Chen,Jana L. Jacobs,Simon M. Barratt-Boyes,John W. Mellors,Ralph S. Baric,Ivet Bahar,Dimiter S. Dimitrov,Sriram Subramaniam,David R. Martinez,Wei Liu +28 more
TL;DR: In this paper , a human VH domain, F6, was characterized by sequentially panning large phage-displayed VH libraries against receptor binding domains (RBDs) containing VOC mutations.