Visceral Abdominal Obesity Is Associated With an Increased Risk of Irritable Bowel Syndrome

1Student`s Research Committee, Department of Nutrition, Tabriz University of Medical Science, Tabriz, Iran 2Department of Nutrition, Maragheh University of Medical Sciences, Maragheh, Iran 3Medical Student, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran 4Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran 5Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran More Information

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The review of the relationship between UCP2 and obesity: Focusing on inflammatory-obesity

Publications List 30 cont.p4 Understanding immunity through measurements of the single cell Single cell analysis (cytometry) is a critical tool for understanding biological systems composed of heterogeneous cell populations. In such systems, complex interactions between a large number of individual cells defi ne the biological behaviour of the system. Conclusions drawn from bulk measurements that average cellular information – even when they contain many thousands of parameters (e.g. microarray or RNA-seq) – can never provide the degree of mechanistic understanding that is routinely derived from a single cell analysis of the entire population of cells. Important features present in small sub-populations can be obscured or missed completely in a population-based analysis, as can co-variance of multiple characteristics throughout the population. When cancer is involved the situation is even more diffi cult, as heterogeneity exists at all levels from cancer types to individual patients and even to the point of spatial and/or temporal variation within the one patient. Single cell analysis is therefore a critical technique underpinning the analysis of primary cell populations, and provides data that is both complementary to, and necessary for, understanding the biological context of genomic, proteomic and functional analyses.

High-dimensional single cell mass cytometry (CyTOF) comes to Australia with the establishment of the Ramaciotti Facility for Human Systems Biology

As the prevalence of obesity and associated disease continues to rise and concerns for the spiralling economic and social costs also escalate, innovative management strategies beyond primary prevention and traditional lifestyle interventions are urgently needed. The biological basis of disease is one avenue for further exploration in this context. Several key infl ammatory markers have been consistently associated with both obesity and risk of adverse outcomes in obesity-associated diseases, which suggests that a persistent, low-grade, infl ammatory response is a potentially modifi able risk factor. In this Review, we provide evidence supporting perturbation of the intestinal microbiota and changes in intestinal permeability as potential triggers of infl ammation in obesity. Further characterisation of the mechanisms underpinning the triggers of such infl ammatory responses in overweight and obese individuals could off er unique opportunities for intervention strategies to help ameliorate the risk of obesity-associated disease.

Obesity, infl ammation, and the gut microbiota

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Obesity, infl ammation, and the gut microbiota