A. Henriksen
Novo Nordisk
13 Papers
31 Citations
A. Henriksen is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Antibody & Inflammatory bowel disease. The author has an hindex of 5, co-authored 13 publications.
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Papers
Structure and function of α-glucan debranching enzymes
TL;DR: The phylogenetic analysis indicated that GH13_39 enzymes could represent a “missing link” between the strictly α-1,6-specific debranching enzymes and the enzymes with dual specificity and α- 1,4-linkage preference.
A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Henrik Østergaard,Jacob Lund,Per Jr Greisen,Stine Kjellev,A. Henriksen,Nikolai Lorenzen,Eva Johansson,Gustav Røder,Morten Grønbech Rasch,Laust Bruun Johnsen,Thomas Egebjerg,Søren Lund,Henrik Rahbek-Nielsen,Prafull S. Gandhi,Kasper Lamberth,Mette Loftager,Lisbeth Moreau Andersen,Amalie Carnbring Bonde,Fabian Stavenuiter,Daniel Elenius Madsen,Xun Li,Thomas Lindebo Holm,Carsten Dan Ley,Peter Thygesen,Haisun Zhu,Rong Zhou,Karina Thorn,Zhiru Yang,Mette B. Hermit,Jais Rose Bjelke,Bjarne Gram Hansen,Ida Hilden +31 more
TL;DR: Mim8 as mentioned in this paper is an activated FVIII mimetic with a potent and efficacious hemostatic effect based on preclinical data, which is a bispecific antibody assembled with FIXa and FX on membranes, and supported activation with an apparent equilibrium dissociation constant of 16 nM.
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A Comprehensive Evaluation of Nanoparticle Tracking Analysis (NanoSight) for Characterization of Proteinaceous Submicron Particles
Xinsheng Tian,Xinsheng Tian,M. Reza Nejadnik,Dorrit Baunsgaard,A. Henriksen,Christian Rischel,Wim Jiskoot +6 more
TL;DR: NTA analysis can be used as a robust stability-indicating method for the characterization of proteinaceous submicron particles and thereby complement other analytical methods, provided that consistent sample handling and parametric settings are established for the specific case study.
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Patent
Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
Vibeke Westphal Stennicke,Christine Brender Read,Susanne Nedergaard Grell,Charlotte Wiberg,Rune Salbo,A. Henriksen,Soeren Padkjaer +6 more
- 30 Nov 2012
TL;DR: In this paper, the authors proposed a method to prevent the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils, in the treatment of individuals with an inflammatory disease.
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